Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium
Titanium is commonly used for medical devices, including osseointegrating implants, owing to its biocompatibility and mechanical properties. Nanostructuring titanium implants is known to enhance the healing process by promoting bone growth on the implant surface. Hydroxyapatite nanoparticles, resemb...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-10-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202300051 |
| _version_ | 1797659549452206080 |
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| author | Gustav Eriksson Mats Hulander Mattias Thuvander Martin Andersson |
| author_facet | Gustav Eriksson Mats Hulander Mattias Thuvander Martin Andersson |
| author_sort | Gustav Eriksson |
| collection | DOAJ |
| description | Titanium is commonly used for medical devices, including osseointegrating implants, owing to its biocompatibility and mechanical properties. Nanostructuring titanium implants is known to enhance the healing process by promoting bone growth on the implant surface. Hydroxyapatite nanoparticles, resembling natural bone mineral, have been used to further improve osseointegration. While previous studies have investigated the osseointegration of titanium implants using atom probe tomography, limited research has focused on the attachment of synthetic hydroxyapatite to titanium. Herein, electron microscopy and atom probe tomography are used to reveal the assembly of synthetic hydroxyapatite nanoparticles in the titanium oxide surface. By sputter coating with chromium, a suitable matrix is formed for detailed interfacial analysis. The results demonstrate the diffusion of calcium, phosphorus, and carbon from hydroxyapatite nanoparticles into the titanium oxide surface. |
| first_indexed | 2024-03-11T18:16:43Z |
| format | Article |
| id | doaj.art-f42442e923b946bda63fe19fe70e6feb |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-11T18:16:43Z |
| publishDate | 2023-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-f42442e923b946bda63fe19fe70e6feb2023-10-16T07:03:54ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-10-01310n/an/a10.1002/anbr.202300051Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on TitaniumGustav Eriksson0Mats Hulander1Mattias Thuvander2Martin Andersson3Department of Chemistry and Chemical Engineering Chalmers University of Technology SE-41296 Gothenburg SwedenDepartment of Chemistry and Chemical Engineering Chalmers University of Technology SE-41296 Gothenburg SwedenDepartment of Physics Chalmers University of Technology SE-41296 Gothenburg SwedenDepartment of Chemistry and Chemical Engineering Chalmers University of Technology SE-41296 Gothenburg SwedenTitanium is commonly used for medical devices, including osseointegrating implants, owing to its biocompatibility and mechanical properties. Nanostructuring titanium implants is known to enhance the healing process by promoting bone growth on the implant surface. Hydroxyapatite nanoparticles, resembling natural bone mineral, have been used to further improve osseointegration. While previous studies have investigated the osseointegration of titanium implants using atom probe tomography, limited research has focused on the attachment of synthetic hydroxyapatite to titanium. Herein, electron microscopy and atom probe tomography are used to reveal the assembly of synthetic hydroxyapatite nanoparticles in the titanium oxide surface. By sputter coating with chromium, a suitable matrix is formed for detailed interfacial analysis. The results demonstrate the diffusion of calcium, phosphorus, and carbon from hydroxyapatite nanoparticles into the titanium oxide surface.https://doi.org/10.1002/anbr.202300051atom probe tomographyhydroxyapatiteintegrationnanoparticlestitaniumtransmission electron microscopy |
| spellingShingle | Gustav Eriksson Mats Hulander Mattias Thuvander Martin Andersson Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium Advanced NanoBiomed Research atom probe tomography hydroxyapatite integration nanoparticles titanium transmission electron microscopy |
| title | Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium |
| title_full | Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium |
| title_fullStr | Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium |
| title_full_unstemmed | Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium |
| title_short | Atomically Resolved Interfacial Analysis of Bone‐Like Hydroxyapatite Nanoparticles on Titanium |
| title_sort | atomically resolved interfacial analysis of bone like hydroxyapatite nanoparticles on titanium |
| topic | atom probe tomography hydroxyapatite integration nanoparticles titanium transmission electron microscopy |
| url | https://doi.org/10.1002/anbr.202300051 |
| work_keys_str_mv | AT gustaveriksson atomicallyresolvedinterfacialanalysisofbonelikehydroxyapatitenanoparticlesontitanium AT matshulander atomicallyresolvedinterfacialanalysisofbonelikehydroxyapatitenanoparticlesontitanium AT mattiasthuvander atomicallyresolvedinterfacialanalysisofbonelikehydroxyapatitenanoparticlesontitanium AT martinandersson atomicallyresolvedinterfacialanalysisofbonelikehydroxyapatitenanoparticlesontitanium |