Clinical factors associated with unipolar mania: A systematic review and meta-analysis
Introduction The existence of a clinical entity on the spectrum of mood disorders characterized by the occurrence of manic episodes without major depressive episodes (Unipolar Mania, UM) is largely debated. Although not classified nosologically, the studies exploring this topic have suggested that...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823010751/type/journal_article |
| _version_ | 1797616893859725312 |
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| author | F. Bartoli C. Nasti D. Palpella S. Piacenti M. E. Di Lella S. Mauro L. Prestifilippo C. Crocamo G. Carrà |
| author_facet | F. Bartoli C. Nasti D. Palpella S. Piacenti M. E. Di Lella S. Mauro L. Prestifilippo C. Crocamo G. Carrà |
| author_sort | F. Bartoli |
| collection | DOAJ |
| description |
Introduction
The existence of a clinical entity on the spectrum of mood disorders characterized by the occurrence of manic episodes without major depressive episodes (Unipolar Mania, UM) is largely debated. Although not classified nosologically, the studies exploring this topic have suggested that UM might differ from bipolar disorder with a manic-depressive course (md-BD), in terms of several clinical characteristics. Individuals with UM might represent a subpopulation with specific clinical profiles and unmet care needs, requiring personalized treatments, as compared with those suffering from md-BD.
Objectives
To identify clinical factors associated with UM, as compared with md-BD.
Methods
We performed a systematic review and meta-analysis of observational studies according to the MOOSE guidelines. We searched for articles indexed up to July 2022 in the main electronic databases. We conducted random-effects meta-analyses of the association between UM and relevant correlates, using odds ratio for categorical variables and standardized mean difference for continuous variables.
Results
Based on data from 21 studies meeting the eligibility criteria, we found that individuals with UM, as compared with md-BD, were more likely to be males (p = 0.007) and to have an earlier age at onset (p = 0.020). Moreover, UM was significantly associated with a higher number of hospitalizations (p < 0.001), the occurrence of psychotic features (p < 0.001), as well as hyperthymic temperament (p = 0.012). Finally, subjects with UM were less likely to report a family history of depression (p = 0.006) and a personal history of suicide attempts (p < 0.001).
Conclusions
Our work supports the hypothesis that UM might represent a distinctive diagnostic construct, with peculiar clinical correlates. Additional research is needed to better differentiate UM in the context of affective disorders.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:47:47Z |
| format | Article |
| id | doaj.art-f424a9ec18dc4204bd0ed92ff937d4ba |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:47:47Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-f424a9ec18dc4204bd0ed92ff937d4ba2023-11-17T05:07:25ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S506S50610.1192/j.eurpsy.2023.1075Clinical factors associated with unipolar mania: A systematic review and meta-analysisF. Bartoli0C. Nasti1D. Palpella2S. Piacenti3M. E. Di Lella4S. Mauro5L. Prestifilippo6C. Crocamo7G. Carrà8Department of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, ItalyDepartment of Medicine and Surgery, Università degli Studi di Milano - Bicocca, Milan, Italy Division of Psychiatry, University College London, London, United Kingdom Introduction The existence of a clinical entity on the spectrum of mood disorders characterized by the occurrence of manic episodes without major depressive episodes (Unipolar Mania, UM) is largely debated. Although not classified nosologically, the studies exploring this topic have suggested that UM might differ from bipolar disorder with a manic-depressive course (md-BD), in terms of several clinical characteristics. Individuals with UM might represent a subpopulation with specific clinical profiles and unmet care needs, requiring personalized treatments, as compared with those suffering from md-BD. Objectives To identify clinical factors associated with UM, as compared with md-BD. Methods We performed a systematic review and meta-analysis of observational studies according to the MOOSE guidelines. We searched for articles indexed up to July 2022 in the main electronic databases. We conducted random-effects meta-analyses of the association between UM and relevant correlates, using odds ratio for categorical variables and standardized mean difference for continuous variables. Results Based on data from 21 studies meeting the eligibility criteria, we found that individuals with UM, as compared with md-BD, were more likely to be males (p = 0.007) and to have an earlier age at onset (p = 0.020). Moreover, UM was significantly associated with a higher number of hospitalizations (p < 0.001), the occurrence of psychotic features (p < 0.001), as well as hyperthymic temperament (p = 0.012). Finally, subjects with UM were less likely to report a family history of depression (p = 0.006) and a personal history of suicide attempts (p < 0.001). Conclusions Our work supports the hypothesis that UM might represent a distinctive diagnostic construct, with peculiar clinical correlates. Additional research is needed to better differentiate UM in the context of affective disorders. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823010751/type/journal_article |
| spellingShingle | F. Bartoli C. Nasti D. Palpella S. Piacenti M. E. Di Lella S. Mauro L. Prestifilippo C. Crocamo G. Carrà Clinical factors associated with unipolar mania: A systematic review and meta-analysis European Psychiatry |
| title | Clinical factors associated with unipolar mania: A systematic review and meta-analysis |
| title_full | Clinical factors associated with unipolar mania: A systematic review and meta-analysis |
| title_fullStr | Clinical factors associated with unipolar mania: A systematic review and meta-analysis |
| title_full_unstemmed | Clinical factors associated with unipolar mania: A systematic review and meta-analysis |
| title_short | Clinical factors associated with unipolar mania: A systematic review and meta-analysis |
| title_sort | clinical factors associated with unipolar mania a systematic review and meta analysis |
| url | https://www.cambridge.org/core/product/identifier/S0924933823010751/type/journal_article |
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