Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentia...
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Bibliographic Details
| Main Authors: |
Lucia Cabal-Hierro,
Peter van Galen,
Miguel A. Prado,
Kelly J. Higby,
Katsuhiro Togami,
Cody T. Mowery,
Joao A. Paulo,
Yingtian Xie,
Paloma Cejas,
Takashi Furusawa,
Michael Bustin,
Henry W. Long,
David B. Sykes,
Steven P. Gygi,
Daniel Finley,
Bradley E. Bernstein,
Andrew A. Lane |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-15221-z
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