Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentia...

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Main Authors: Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15221-z
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author Lucia Cabal-Hierro
Peter van Galen
Miguel A. Prado
Kelly J. Higby
Katsuhiro Togami
Cody T. Mowery
Joao A. Paulo
Yingtian Xie
Paloma Cejas
Takashi Furusawa
Michael Bustin
Henry W. Long
David B. Sykes
Steven P. Gygi
Daniel Finley
Bradley E. Bernstein
Andrew A. Lane
author_facet Lucia Cabal-Hierro
Peter van Galen
Miguel A. Prado
Kelly J. Higby
Katsuhiro Togami
Cody T. Mowery
Joao A. Paulo
Yingtian Xie
Paloma Cejas
Takashi Furusawa
Michael Bustin
Henry W. Long
David B. Sykes
Steven P. Gygi
Daniel Finley
Bradley E. Bernstein
Andrew A. Lane
author_sort Lucia Cabal-Hierro
collection DOAJ
description Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation.
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spelling doaj.art-f424d9b406fb49f7a429fe6474f60a2d2022-12-21T19:27:54ZengNature PortfolioNature Communications2041-17232020-03-0111111810.1038/s41467-020-15221-zChromatin accessibility promotes hematopoietic and leukemia stem cell activityLucia Cabal-Hierro0Peter van Galen1Miguel A. Prado2Kelly J. Higby3Katsuhiro Togami4Cody T. Mowery5Joao A. Paulo6Yingtian Xie7Paloma Cejas8Takashi Furusawa9Michael Bustin10Henry W. Long11David B. Sykes12Steven P. Gygi13Daniel Finley14Bradley E. Bernstein15Andrew A. Lane16Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolBroad Institute of Harvard and MITDepartment of Cell Biology, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cell Biology, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolLaboratory of Metabolism, National Cancer InstituteLaboratory of Metabolism, National Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolCenter for Regenerative Medicine, Massachusetts General HospitalDepartment of Cell Biology, Harvard Medical SchoolDepartment of Cell Biology, Harvard Medical SchoolBroad Institute of Harvard and MITDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolChromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation.https://doi.org/10.1038/s41467-020-15221-z
spellingShingle Lucia Cabal-Hierro
Peter van Galen
Miguel A. Prado
Kelly J. Higby
Katsuhiro Togami
Cody T. Mowery
Joao A. Paulo
Yingtian Xie
Paloma Cejas
Takashi Furusawa
Michael Bustin
Henry W. Long
David B. Sykes
Steven P. Gygi
Daniel Finley
Bradley E. Bernstein
Andrew A. Lane
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
Nature Communications
title Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_full Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_fullStr Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_full_unstemmed Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_short Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_sort chromatin accessibility promotes hematopoietic and leukemia stem cell activity
url https://doi.org/10.1038/s41467-020-15221-z
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