Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentia...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2020-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15221-z |
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author | Lucia Cabal-Hierro Peter van Galen Miguel A. Prado Kelly J. Higby Katsuhiro Togami Cody T. Mowery Joao A. Paulo Yingtian Xie Paloma Cejas Takashi Furusawa Michael Bustin Henry W. Long David B. Sykes Steven P. Gygi Daniel Finley Bradley E. Bernstein Andrew A. Lane |
author_facet | Lucia Cabal-Hierro Peter van Galen Miguel A. Prado Kelly J. Higby Katsuhiro Togami Cody T. Mowery Joao A. Paulo Yingtian Xie Paloma Cejas Takashi Furusawa Michael Bustin Henry W. Long David B. Sykes Steven P. Gygi Daniel Finley Bradley E. Bernstein Andrew A. Lane |
author_sort | Lucia Cabal-Hierro |
collection | DOAJ |
description | Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation. |
first_indexed | 2024-12-20T20:08:24Z |
format | Article |
id | doaj.art-f424d9b406fb49f7a429fe6474f60a2d |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-12-20T20:08:24Z |
publishDate | 2020-03-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-f424d9b406fb49f7a429fe6474f60a2d2022-12-21T19:27:54ZengNature PortfolioNature Communications2041-17232020-03-0111111810.1038/s41467-020-15221-zChromatin accessibility promotes hematopoietic and leukemia stem cell activityLucia Cabal-Hierro0Peter van Galen1Miguel A. Prado2Kelly J. Higby3Katsuhiro Togami4Cody T. Mowery5Joao A. Paulo6Yingtian Xie7Paloma Cejas8Takashi Furusawa9Michael Bustin10Henry W. Long11David B. Sykes12Steven P. Gygi13Daniel Finley14Bradley E. Bernstein15Andrew A. Lane16Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolBroad Institute of Harvard and MITDepartment of Cell Biology, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Cell Biology, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolLaboratory of Metabolism, National Cancer InstituteLaboratory of Metabolism, National Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolCenter for Regenerative Medicine, Massachusetts General HospitalDepartment of Cell Biology, Harvard Medical SchoolDepartment of Cell Biology, Harvard Medical SchoolBroad Institute of Harvard and MITDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical SchoolChromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation.https://doi.org/10.1038/s41467-020-15221-z |
spellingShingle | Lucia Cabal-Hierro Peter van Galen Miguel A. Prado Kelly J. Higby Katsuhiro Togami Cody T. Mowery Joao A. Paulo Yingtian Xie Paloma Cejas Takashi Furusawa Michael Bustin Henry W. Long David B. Sykes Steven P. Gygi Daniel Finley Bradley E. Bernstein Andrew A. Lane Chromatin accessibility promotes hematopoietic and leukemia stem cell activity Nature Communications |
title | Chromatin accessibility promotes hematopoietic and leukemia stem cell activity |
title_full | Chromatin accessibility promotes hematopoietic and leukemia stem cell activity |
title_fullStr | Chromatin accessibility promotes hematopoietic and leukemia stem cell activity |
title_full_unstemmed | Chromatin accessibility promotes hematopoietic and leukemia stem cell activity |
title_short | Chromatin accessibility promotes hematopoietic and leukemia stem cell activity |
title_sort | chromatin accessibility promotes hematopoietic and leukemia stem cell activity |
url | https://doi.org/10.1038/s41467-020-15221-z |
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