An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Δ8-desaturates 20:2n-6 and 20:3n-3

An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Δ8-desaturates 20:2n-6 and 20:3n-3

The mammalian Δ6-desaturase coded by fatty acid desaturase 2 (FADS2; HSA11q12-q13.1) catalyzes the first and rate-limiting step for the biosynthesis of long-chain polyunsaturated fatty acids. FADS2 is known to act on at least five substrates, and we hypothesized that the FADS2 gene product would hav...

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Bibliographic Details
Main Authors:	Woo Jung Park, Kumar S.D. Kothapalli, Peter Lawrence, Cynthia Tyburczy, J. Thomas Brenna
Format:	Article
Language:	English
Published:	Elsevier 2009-06-01
Series:	Journal of Lipid Research
Subjects:	polyunsaturated fatty acid biosynthesis dihomo-γ-linolenic acid eicosanoid precursor biosynthesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520308178

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