Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts

Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts

Abstract Background Glioblastoma (GBM) is a tumor of the central nervous system. After surgical removal and standard therapy, recurrence of tumors is observed within 6–9 months because of the high migratory behavior and the infiltrative growth of cells. Here, we investigated whether carnosine (β-ala...

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Bibliographic Details
Main Authors: Henry Oppermann, Johannes Dietterle, Katharina Purcz, Markus Morawski, Christian Eisenlöffel, Wolf Müller, Jürgen Meixensberger, Frank Gaunitz
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Migration assay
Fibroblast ring co-culture
Carnosine
Online Access:http://link.springer.com/article/10.1186/s12935-018-0611-2

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