A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection
<i>Clostridioides difficile</i> is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe the clinical characteristics, outcomes, and relationship between antibiotic exposure and <i>Clostridioide...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/2/144 |
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| author | Bogdan Ioan Vintila Anca Maria Arseniu Claudiu Morgovan Anca Butuca Victoria Bîrluțiu Carmen Maximiliana Dobrea Luca Liviu Rus Steliana Ghibu Alina Simona Bereanu Rares Arseniu Ioana Roxana Codru Mihai Sava Felicia Gabriela Gligor |
| author_facet | Bogdan Ioan Vintila Anca Maria Arseniu Claudiu Morgovan Anca Butuca Victoria Bîrluțiu Carmen Maximiliana Dobrea Luca Liviu Rus Steliana Ghibu Alina Simona Bereanu Rares Arseniu Ioana Roxana Codru Mihai Sava Felicia Gabriela Gligor |
| author_sort | Bogdan Ioan Vintila |
| collection | DOAJ |
| description | <i>Clostridioides difficile</i> is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe the clinical characteristics, outcomes, and relationship between antibiotic exposure and <i>Clostridioides difficile</i> infection (CDI) in patients based on reports from two databases. Thus, we conducted a retrospective study of patients diagnosed with CDI from Sibiu County Clinical Emergency Hospital (SCCEH), Romania, followed by a descriptive analysis based on spontaneous reports submitted to the EudraVigilance (EV) database. From 1 January to 31 December 2022, we included 111 hospitalized patients with CDI from SCCEH. Moreover, 249 individual case safety reports (ICSRs) from EVs were analyzed. According to the data collected from SCCEH, CDI was most frequently reported in patients aged 65–85 years (66.7%) and in females (55%). In total, 71.2% of all patients showed positive medical progress. Most cases were reported in the internal medicine (n = 30, 27%), general surgery (n = 26, 23.4%), and infectious disease (n = 22, 19.8%) departments. Patients were most frequently exposed to ceftriaxone (CFT) and meropenem (MER). Also, in the EV database, most CDI-related ADRs were reported for CFT, PIP/TAZ (piperacillin/tazobactam), MER, and CPX (ciprofloxacin). Understanding the association between previous antibiotic exposure and the risk of CDI may help update antibiotic stewardship protocols and reduce the incidence of CDI by lowering exposure to high-risk antibiotics. |
| first_indexed | 2024-03-07T22:45:04Z |
| format | Article |
| id | doaj.art-f429e19423d94fc9bdaabed380b40d61 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-07T22:45:04Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f429e19423d94fc9bdaabed380b40d612024-02-23T15:05:03ZengMDPI AGAntibiotics2079-63822024-02-0113214410.3390/antibiotics13020144A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> InfectionBogdan Ioan Vintila0Anca Maria Arseniu1Claudiu Morgovan2Anca Butuca3Victoria Bîrluțiu4Carmen Maximiliana Dobrea5Luca Liviu Rus6Steliana Ghibu7Alina Simona Bereanu8Rares Arseniu9Ioana Roxana Codru10Mihai Sava11Felicia Gabriela Gligor12Clinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaCounty Clinical Emergency Hospital, 550245 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaDepartment of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaClinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaCounty Emergency Clinical Hospital ”Pius Brînzeu”, 300723 Timișoara, RomaniaClinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaClinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, Romania<i>Clostridioides difficile</i> is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe the clinical characteristics, outcomes, and relationship between antibiotic exposure and <i>Clostridioides difficile</i> infection (CDI) in patients based on reports from two databases. Thus, we conducted a retrospective study of patients diagnosed with CDI from Sibiu County Clinical Emergency Hospital (SCCEH), Romania, followed by a descriptive analysis based on spontaneous reports submitted to the EudraVigilance (EV) database. From 1 January to 31 December 2022, we included 111 hospitalized patients with CDI from SCCEH. Moreover, 249 individual case safety reports (ICSRs) from EVs were analyzed. According to the data collected from SCCEH, CDI was most frequently reported in patients aged 65–85 years (66.7%) and in females (55%). In total, 71.2% of all patients showed positive medical progress. Most cases were reported in the internal medicine (n = 30, 27%), general surgery (n = 26, 23.4%), and infectious disease (n = 22, 19.8%) departments. Patients were most frequently exposed to ceftriaxone (CFT) and meropenem (MER). Also, in the EV database, most CDI-related ADRs were reported for CFT, PIP/TAZ (piperacillin/tazobactam), MER, and CPX (ciprofloxacin). Understanding the association between previous antibiotic exposure and the risk of CDI may help update antibiotic stewardship protocols and reduce the incidence of CDI by lowering exposure to high-risk antibiotics.https://www.mdpi.com/2079-6382/13/2/144<i>Clostridioides difficile</i><i>Clostridioides difficile</i> infectionsCDIantibiotic exposureEudraVigilancesingle-center retrospective study |
| spellingShingle | Bogdan Ioan Vintila Anca Maria Arseniu Claudiu Morgovan Anca Butuca Victoria Bîrluțiu Carmen Maximiliana Dobrea Luca Liviu Rus Steliana Ghibu Alina Simona Bereanu Rares Arseniu Ioana Roxana Codru Mihai Sava Felicia Gabriela Gligor A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection Antibiotics <i>Clostridioides difficile</i> <i>Clostridioides difficile</i> infections CDI antibiotic exposure EudraVigilance single-center retrospective study |
| title | A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection |
| title_full | A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection |
| title_fullStr | A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection |
| title_full_unstemmed | A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection |
| title_short | A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and <i>Clostridioides difficile</i> Infection |
| title_sort | real world study on the clinical characteristics outcomes and relationship between antibiotic exposure and i clostridioides difficile i infection |
| topic | <i>Clostridioides difficile</i> <i>Clostridioides difficile</i> infections CDI antibiotic exposure EudraVigilance single-center retrospective study |
| url | https://www.mdpi.com/2079-6382/13/2/144 |
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