Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in str...
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Frontiers Media S.A.
2018-02-01
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Series: | Frontiers in Molecular Neuroscience |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2018.00032/full |
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author | Nicola Maggio Nicola Maggio Nicola Maggio Efrat Shavit Stein Menahem Segal |
author_facet | Nicola Maggio Nicola Maggio Nicola Maggio Efrat Shavit Stein Menahem Segal |
author_sort | Nicola Maggio |
collection | DOAJ |
description | Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in stratum radiatum of CA1 region of the mouse hippocampus. Exposure to seizure-producing pilocarpine reduced the ability to generate LTP in the slice. Pre-exposure to CBD prevented this effect of pilocarpine. Furthermore, CBD caused a marked increase in ability to generate LTP, an effect that was blocked by calcium store antagonists as well as by a reduction in serotonin tone. Serotonin, possibly acting at a 5HT1A receptor, or fenfluramine (FFA), which causes release of serotonin from its native terminals, mimicked the effect of CBD. It is proposed that CBD enhances non-NMDA LTP in the slice by facilitating release of serotonin from terminals, consequently ameliorating the detrimental effects of pilocarpine. |
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issn | 1662-5099 |
language | English |
last_indexed | 2024-12-21T01:56:36Z |
publishDate | 2018-02-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Molecular Neuroscience |
spelling | doaj.art-f42c625b3b0a4d6885d396202b5ad36d2022-12-21T19:19:45ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992018-02-011110.3389/fnmol.2018.00032306590Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and SerotoninNicola Maggio0Nicola Maggio1Nicola Maggio2Efrat Shavit Stein3Menahem Segal4Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, IsraelDepartment of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThe Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology, The Chaim Sheba Medical Center, Ramat Gan, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, Rehovot, IsraelEpilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in stratum radiatum of CA1 region of the mouse hippocampus. Exposure to seizure-producing pilocarpine reduced the ability to generate LTP in the slice. Pre-exposure to CBD prevented this effect of pilocarpine. Furthermore, CBD caused a marked increase in ability to generate LTP, an effect that was blocked by calcium store antagonists as well as by a reduction in serotonin tone. Serotonin, possibly acting at a 5HT1A receptor, or fenfluramine (FFA), which causes release of serotonin from its native terminals, mimicked the effect of CBD. It is proposed that CBD enhances non-NMDA LTP in the slice by facilitating release of serotonin from terminals, consequently ameliorating the detrimental effects of pilocarpine.http://journal.frontiersin.org/article/10.3389/fnmol.2018.00032/fullstatus epilepticussynaptic plasticityLTPcannabidiolserotoninhippocampus |
spellingShingle | Nicola Maggio Nicola Maggio Nicola Maggio Efrat Shavit Stein Menahem Segal Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin Frontiers in Molecular Neuroscience status epilepticus synaptic plasticity LTP cannabidiol serotonin hippocampus |
title | Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin |
title_full | Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin |
title_fullStr | Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin |
title_full_unstemmed | Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin |
title_short | Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin |
title_sort | cannabidiol regulates long term potentiation following status epilepticus mediation by calcium stores and serotonin |
topic | status epilepticus synaptic plasticity LTP cannabidiol serotonin hippocampus |
url | http://journal.frontiersin.org/article/10.3389/fnmol.2018.00032/full |
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