Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin

Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in str...

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Main Authors: Nicola Maggio, Efrat Shavit Stein, Menahem Segal
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00032/full
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author Nicola Maggio
Nicola Maggio
Nicola Maggio
Efrat Shavit Stein
Menahem Segal
author_facet Nicola Maggio
Nicola Maggio
Nicola Maggio
Efrat Shavit Stein
Menahem Segal
author_sort Nicola Maggio
collection DOAJ
description Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in stratum radiatum of CA1 region of the mouse hippocampus. Exposure to seizure-producing pilocarpine reduced the ability to generate LTP in the slice. Pre-exposure to CBD prevented this effect of pilocarpine. Furthermore, CBD caused a marked increase in ability to generate LTP, an effect that was blocked by calcium store antagonists as well as by a reduction in serotonin tone. Serotonin, possibly acting at a 5HT1A receptor, or fenfluramine (FFA), which causes release of serotonin from its native terminals, mimicked the effect of CBD. It is proposed that CBD enhances non-NMDA LTP in the slice by facilitating release of serotonin from terminals, consequently ameliorating the detrimental effects of pilocarpine.
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spelling doaj.art-f42c625b3b0a4d6885d396202b5ad36d2022-12-21T19:19:45ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992018-02-011110.3389/fnmol.2018.00032306590Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and SerotoninNicola Maggio0Nicola Maggio1Nicola Maggio2Efrat Shavit Stein3Menahem Segal4Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, IsraelDepartment of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThe Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology, The Chaim Sheba Medical Center, Ramat Gan, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, Rehovot, IsraelEpilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy. We have studied the effects of cannabidiol (CBD) on the ability to produce long term potentiation (LTP) in stratum radiatum of CA1 region of the mouse hippocampus. Exposure to seizure-producing pilocarpine reduced the ability to generate LTP in the slice. Pre-exposure to CBD prevented this effect of pilocarpine. Furthermore, CBD caused a marked increase in ability to generate LTP, an effect that was blocked by calcium store antagonists as well as by a reduction in serotonin tone. Serotonin, possibly acting at a 5HT1A receptor, or fenfluramine (FFA), which causes release of serotonin from its native terminals, mimicked the effect of CBD. It is proposed that CBD enhances non-NMDA LTP in the slice by facilitating release of serotonin from terminals, consequently ameliorating the detrimental effects of pilocarpine.http://journal.frontiersin.org/article/10.3389/fnmol.2018.00032/fullstatus epilepticussynaptic plasticityLTPcannabidiolserotoninhippocampus
spellingShingle Nicola Maggio
Nicola Maggio
Nicola Maggio
Efrat Shavit Stein
Menahem Segal
Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
Frontiers in Molecular Neuroscience
status epilepticus
synaptic plasticity
LTP
cannabidiol
serotonin
hippocampus
title Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
title_full Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
title_fullStr Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
title_full_unstemmed Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
title_short Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
title_sort cannabidiol regulates long term potentiation following status epilepticus mediation by calcium stores and serotonin
topic status epilepticus
synaptic plasticity
LTP
cannabidiol
serotonin
hippocampus
url http://journal.frontiersin.org/article/10.3389/fnmol.2018.00032/full
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