Visual electrophy siological tests in obstructive sleep apnoea
AIM:To compare the pattern electroretinogram(PERG)and pattern visual evoked potential(PVEP)between obstructive sleep apnoea(OSA)patients and controls. <p>METHODS: This was a prospective cross-sectional study involving 40 OSA patients and 31 control subjects in Hospital Universiti Sains Malaysi...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-07-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2017/7/201707005.pdf |
| _version_ | 1811255814215696384 |
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| author | Seok Hui Ng Evelyn Tai Li Min Baharudin Abdullah Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam |
| author_facet | Seok Hui Ng Evelyn Tai Li Min Baharudin Abdullah Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam |
| author_sort | Seok Hui Ng |
| collection | DOAJ |
| description | AIM:To compare the pattern electroretinogram(PERG)and pattern visual evoked potential(PVEP)between obstructive sleep apnoea(OSA)patients and controls. <p>METHODS: This was a prospective cross-sectional study involving 40 OSA patients and 31 control subjects in Hospital Universiti Sains Malaysia. Patients with a confirmed diagnosis of OSA who had no ocular pathology were randomly selected to participate in the study. The apnoea-hypopnoea index(AHI)was obtained from their records and used for stratification of OSA severity. Electrophysiological tests(PVEP and PERG)were performed on each patient by a trained technician in the electrophysiology laboratory of the Department of Ophthalmology, USM. The results obtained were recorded as median values. Data analysis was done using IBM Statistics Version 21.0.<p>RESULTS: Among OSA patients, we observed a significant reduction of the PERG amplitude P50(<i>P<</i>0.001)and the PVEP amplitude P100(<i>P<</i>0.001)compared to the control group. OSA patients also had a significant increase in PVEP time to peak P100(<i>P=</i>0.003)and time to peak N75(<i>P=</i>0.004). However, no significant differences were detected in PERG time to peak between OSA patients and controls. There were likewise no significant differences in PVEP or PERG between OSA patients with different disease severity.<p>CONCLUSION: OSA patients have significant abnormalities in PVEP amplitude and time to peak, as well as PERG amplitude. This may reflect subclinical optic nerve dysfunction in OSA. Further research is needed to determine the association between the severity of OSA and the degree of optic nerve dysfunction. |
| first_indexed | 2024-04-12T17:30:39Z |
| format | Article |
| id | doaj.art-f42e142cb70c48cc8460a045e70d8b41 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-04-12T17:30:39Z |
| publishDate | 2017-07-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-f42e142cb70c48cc8460a045e70d8b412022-12-22T03:23:09ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-07-011771215122010.3980/j.issn.1672-5123.2017.7.05Visual electrophy siological tests in obstructive sleep apnoeaSeok Hui Ng0Evelyn Tai Li Min1Baharudin Abdullah2Raja Azmi Mohd Noor3Wan-Hazabbah Wan Hitam4Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia<sup>2</sup>Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia<sup>2</sup>Hospital Universiti Sains Malaysia, Kubang Kerian 16151, Kelantan, Malaysia<sup>2</sup>Department of Otorhinolaryngology, Head and Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia;<sup>3</sup>Department of Otorhinolaryngology, Head and Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia<sup>2</sup>Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia<sup>2</sup>Hospital Universiti Sains Malaysia, Kubang Kerian 16151, Kelantan, MalaysiaAIM:To compare the pattern electroretinogram(PERG)and pattern visual evoked potential(PVEP)between obstructive sleep apnoea(OSA)patients and controls. <p>METHODS: This was a prospective cross-sectional study involving 40 OSA patients and 31 control subjects in Hospital Universiti Sains Malaysia. Patients with a confirmed diagnosis of OSA who had no ocular pathology were randomly selected to participate in the study. The apnoea-hypopnoea index(AHI)was obtained from their records and used for stratification of OSA severity. Electrophysiological tests(PVEP and PERG)were performed on each patient by a trained technician in the electrophysiology laboratory of the Department of Ophthalmology, USM. The results obtained were recorded as median values. Data analysis was done using IBM Statistics Version 21.0.<p>RESULTS: Among OSA patients, we observed a significant reduction of the PERG amplitude P50(<i>P<</i>0.001)and the PVEP amplitude P100(<i>P<</i>0.001)compared to the control group. OSA patients also had a significant increase in PVEP time to peak P100(<i>P=</i>0.003)and time to peak N75(<i>P=</i>0.004). However, no significant differences were detected in PERG time to peak between OSA patients and controls. There were likewise no significant differences in PVEP or PERG between OSA patients with different disease severity.<p>CONCLUSION: OSA patients have significant abnormalities in PVEP amplitude and time to peak, as well as PERG amplitude. This may reflect subclinical optic nerve dysfunction in OSA. Further research is needed to determine the association between the severity of OSA and the degree of optic nerve dysfunction.http://ies.ijo.cn/cn_publish/2017/7/201707005.pdfobstructive sleep apnoeaapnoea-hypopnoea indexpattern visual evoked potentialpattern electroretinogrampattern electroretinogram |
| spellingShingle | Seok Hui Ng Evelyn Tai Li Min Baharudin Abdullah Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam Visual electrophy siological tests in obstructive sleep apnoea Guoji Yanke Zazhi obstructive sleep apnoea apnoea-hypopnoea index pattern visual evoked potential pattern electroretinogram pattern electroretinogram |
| title | Visual electrophy siological tests in obstructive sleep apnoea |
| title_full | Visual electrophy siological tests in obstructive sleep apnoea |
| title_fullStr | Visual electrophy siological tests in obstructive sleep apnoea |
| title_full_unstemmed | Visual electrophy siological tests in obstructive sleep apnoea |
| title_short | Visual electrophy siological tests in obstructive sleep apnoea |
| title_sort | visual electrophy siological tests in obstructive sleep apnoea |
| topic | obstructive sleep apnoea apnoea-hypopnoea index pattern visual evoked potential pattern electroretinogram pattern electroretinogram |
| url | http://ies.ijo.cn/cn_publish/2017/7/201707005.pdf |
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