Corneal higher-order aberration changes after accelerated cross-linking for keratoconus
Abstract Aim To evaluate changes in corneal higher-order aberrations (HOAs) following epithelium-off accelerated corneal cross-linking (A-CXL) and to explore the impact on visual acuity. Methods In this retrospective case series, 32 eyes of 24 patients with keratoconus (KC) underwent A-CXL. Treatmen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02457-0 |
| _version_ | 1811341136781901824 |
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| author | Abdelrahman Salman Marwan Ghabra Taym R. Darwish Obeda Kailani Hussein Ibrahim Hakam Ghabra |
| author_facet | Abdelrahman Salman Marwan Ghabra Taym R. Darwish Obeda Kailani Hussein Ibrahim Hakam Ghabra |
| author_sort | Abdelrahman Salman |
| collection | DOAJ |
| description | Abstract Aim To evaluate changes in corneal higher-order aberrations (HOAs) following epithelium-off accelerated corneal cross-linking (A-CXL) and to explore the impact on visual acuity. Methods In this retrospective case series, 32 eyes of 24 patients with keratoconus (KC) underwent A-CXL. Treatment was delivered at 10 mW/cm2 for 9 min with a total dose of 5.4 J/cm2. The following anterior corneal HOAs: total corneal HOAs, trefoil, secondary trefoil, coma, secondary coma, secondary astigmatism and spherical aberrations were analysed using the Scheimpflug-Placido Sirius (CSO, Italy) corneal topographer at baseline and 12 months following treatment. Multivariate analysis was used to evaluate the independent effect of HOA subtypes on changes in uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA). Results At one year post CXL, UDVA and CDVA were significantly improved, -0.13 ± 0.19 LogMAR (P = 0.0005) and -0.08 ± .0.11 LogMAR (P = 0.0003), respectively. The mean preoperative trefoil, secondary trefoil, secondary coma and secondary astigmatism were 0.95 ± 0.46; µm, 0.20 ± 0.11; µm, 0.29 ± 0.19; µm and 0.42 ± 0.17 µm, respectively. At one year, the mean values decreased significantly to 0.77 ± 0.47 µm, 0.15 ± 0.11 µm, 0.25 ± 0.18 µm and 0.34 ± 0.18 µm, respectively (P < 0.05, for all). No independent relationship between any HOA changes and change in UDVA was observed. A reduction in secondary coma aberration was associated with a change in CDVA (95% CI 0.01–1.34, P = 0.048; β = 0.67). Conclusion A 9-min protocol of Accelerated corneal cross-linking is an effective treatment in improving corneal HOAs at 12 months follow up, in eyes with progressive keratoconus at one year follow-up. A change in secondary coma had a statistically significant and independent effect on CDVA. |
| first_indexed | 2024-04-13T18:52:17Z |
| format | Article |
| id | doaj.art-f43016bd53d64412a9d1c94159f969b1 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T18:52:17Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-f43016bd53d64412a9d1c94159f969b12022-12-22T02:34:23ZengBMCBMC Ophthalmology1471-24152022-05-012211710.1186/s12886-022-02457-0Corneal higher-order aberration changes after accelerated cross-linking for keratoconusAbdelrahman Salman0Marwan Ghabra1Taym R. Darwish2Obeda Kailani3Hussein Ibrahim4Hakam Ghabra5Tratous Specialist Eye Center, Tishreen UniversityWhipps Cross University HospitalDepartment of Ophthalmology, Tishreen UniversityAKC FRCOphth CertLRS Queen Mary’s Hospital, King’s College Hospital NHS Foundation TrustSurgical Eye Hospital, Health MinistryHarley Street Eye CentreAbstract Aim To evaluate changes in corneal higher-order aberrations (HOAs) following epithelium-off accelerated corneal cross-linking (A-CXL) and to explore the impact on visual acuity. Methods In this retrospective case series, 32 eyes of 24 patients with keratoconus (KC) underwent A-CXL. Treatment was delivered at 10 mW/cm2 for 9 min with a total dose of 5.4 J/cm2. The following anterior corneal HOAs: total corneal HOAs, trefoil, secondary trefoil, coma, secondary coma, secondary astigmatism and spherical aberrations were analysed using the Scheimpflug-Placido Sirius (CSO, Italy) corneal topographer at baseline and 12 months following treatment. Multivariate analysis was used to evaluate the independent effect of HOA subtypes on changes in uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA). Results At one year post CXL, UDVA and CDVA were significantly improved, -0.13 ± 0.19 LogMAR (P = 0.0005) and -0.08 ± .0.11 LogMAR (P = 0.0003), respectively. The mean preoperative trefoil, secondary trefoil, secondary coma and secondary astigmatism were 0.95 ± 0.46; µm, 0.20 ± 0.11; µm, 0.29 ± 0.19; µm and 0.42 ± 0.17 µm, respectively. At one year, the mean values decreased significantly to 0.77 ± 0.47 µm, 0.15 ± 0.11 µm, 0.25 ± 0.18 µm and 0.34 ± 0.18 µm, respectively (P < 0.05, for all). No independent relationship between any HOA changes and change in UDVA was observed. A reduction in secondary coma aberration was associated with a change in CDVA (95% CI 0.01–1.34, P = 0.048; β = 0.67). Conclusion A 9-min protocol of Accelerated corneal cross-linking is an effective treatment in improving corneal HOAs at 12 months follow up, in eyes with progressive keratoconus at one year follow-up. A change in secondary coma had a statistically significant and independent effect on CDVA.https://doi.org/10.1186/s12886-022-02457-0KeratoconusCorneal cross-linkingSiriusHigher order aberrationsScheimpflugTopography |
| spellingShingle | Abdelrahman Salman Marwan Ghabra Taym R. Darwish Obeda Kailani Hussein Ibrahim Hakam Ghabra Corneal higher-order aberration changes after accelerated cross-linking for keratoconus BMC Ophthalmology Keratoconus Corneal cross-linking Sirius Higher order aberrations Scheimpflug Topography |
| title | Corneal higher-order aberration changes after accelerated cross-linking for keratoconus |
| title_full | Corneal higher-order aberration changes after accelerated cross-linking for keratoconus |
| title_fullStr | Corneal higher-order aberration changes after accelerated cross-linking for keratoconus |
| title_full_unstemmed | Corneal higher-order aberration changes after accelerated cross-linking for keratoconus |
| title_short | Corneal higher-order aberration changes after accelerated cross-linking for keratoconus |
| title_sort | corneal higher order aberration changes after accelerated cross linking for keratoconus |
| topic | Keratoconus Corneal cross-linking Sirius Higher order aberrations Scheimpflug Topography |
| url | https://doi.org/10.1186/s12886-022-02457-0 |
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