Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages

Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages

Obesity represents a risk factor for breast cancer development and therapy resistance, but the molecular players underling these links are unclear. Here, we identify a role for the obesity-cytokine leptin in sustaining aromatase inhibitor (AI) resistant growth and progression in breast cancer. Using...

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Bibliographic Details
Main Authors: Luca Gelsomino, Cinzia Giordano, Giusi La Camera, Diego Sisci, Stefania Marsico, Antonella Campana, Roberta Tarallo, Antonio Rinaldi, Suzanne Fuqua, Antonella Leggio, Fedora Grande, Daniela Bonofiglio, Sebastiano Andò, Ines Barone, Stefania Catalano
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
breast cancer
endocrine resistance
leptin
macrophages
obesity
Online Access:https://www.mdpi.com/2218-273X/10/4/543

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