Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy
Objective: Adverse maternal outcomes and perinatal complications are associated with overt and subclinical maternal hypothyroidism. It is not clear whether these complications also occur in women with isolated hypothyroxinemia during pregnancy. The aim of this study was to evaluate the effects of is...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.528146/full |
| _version_ | 1818454373768888320 |
|---|---|
| author | Liangmiao Chen Liangmiao Chen Hong Yang Enling Ye Zhenzhen Lin Mengmeng Peng Hai Lin Lechu Yu Zhuhua Cai Xuemian Lu |
| author_facet | Liangmiao Chen Liangmiao Chen Hong Yang Enling Ye Zhenzhen Lin Mengmeng Peng Hai Lin Lechu Yu Zhuhua Cai Xuemian Lu |
| author_sort | Liangmiao Chen |
| collection | DOAJ |
| description | Objective: Adverse maternal outcomes and perinatal complications are associated with overt and subclinical maternal hypothyroidism. It is not clear whether these complications also occur in women with isolated hypothyroxinemia during pregnancy. The aim of this study was to evaluate the effects of isolated hypothyroxinemia on maternal and perinatal outcomes during pregnancy.Methods: This study included data from 2,864 pregnant women in the first trimester (67 women with isolated hypothyroxinemia, 784 euthyroid women) and the second trimester (70 women with isolated hypothyroxinemia, 1,943 euthyroid women) of pregnancy. Maternal serum samples were collected in the first and second trimesters to examine thyroid hormone concentration. Hypothyroxinemia was defined as a normal maternal thyroid-stimulating hormone concentration with a low maternal free thyroxine concentration and negative thyroid autoantibodies. The following maternal outcomes were recorded: gestational hypertension, gestational diabetes mellitus, placenta previa, placental abruption, prelabor rupture of membranes, and premature delivery. Perinatal outcomes, including fetal growth restriction, fetal distress, low birth weight, intrauterine fetal death, and malformation. The incidence of adverse pregnancy outcomes and perinatal complications was compared between women in the first trimester and second trimester with isolated hypothyroxinemia.Results: There were no significant differences in the incidence rates of adverse maternal outcomes and perinatal complications between patients in the first and second trimesters with isolated hypothyroxinemia.Conclusion: The results of this study indicate that isolated hypothyroidism does not increase the incidence of adverse maternal outcomes and perinatal complications. |
| first_indexed | 2024-12-14T21:53:51Z |
| format | Article |
| id | doaj.art-f432edc56f96423eaa0fa79011e3f060 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T21:53:51Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f432edc56f96423eaa0fa79011e3f0602022-12-21T22:46:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-10-011110.3389/fendo.2020.528146528146Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of PregnancyLiangmiao Chen0Liangmiao Chen1Hong Yang2Enling Ye3Zhenzhen Lin4Mengmeng Peng5Hai Lin6Lechu Yu7Zhuhua Cai8Xuemian Lu9Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Ruian, ChinaObjective: Adverse maternal outcomes and perinatal complications are associated with overt and subclinical maternal hypothyroidism. It is not clear whether these complications also occur in women with isolated hypothyroxinemia during pregnancy. The aim of this study was to evaluate the effects of isolated hypothyroxinemia on maternal and perinatal outcomes during pregnancy.Methods: This study included data from 2,864 pregnant women in the first trimester (67 women with isolated hypothyroxinemia, 784 euthyroid women) and the second trimester (70 women with isolated hypothyroxinemia, 1,943 euthyroid women) of pregnancy. Maternal serum samples were collected in the first and second trimesters to examine thyroid hormone concentration. Hypothyroxinemia was defined as a normal maternal thyroid-stimulating hormone concentration with a low maternal free thyroxine concentration and negative thyroid autoantibodies. The following maternal outcomes were recorded: gestational hypertension, gestational diabetes mellitus, placenta previa, placental abruption, prelabor rupture of membranes, and premature delivery. Perinatal outcomes, including fetal growth restriction, fetal distress, low birth weight, intrauterine fetal death, and malformation. The incidence of adverse pregnancy outcomes and perinatal complications was compared between women in the first trimester and second trimester with isolated hypothyroxinemia.Results: There were no significant differences in the incidence rates of adverse maternal outcomes and perinatal complications between patients in the first and second trimesters with isolated hypothyroxinemia.Conclusion: The results of this study indicate that isolated hypothyroidism does not increase the incidence of adverse maternal outcomes and perinatal complications.https://www.frontiersin.org/article/10.3389/fendo.2020.528146/fullisolated hypothyroxinemiafirst trimestersecond trimesterpregnancy outcomematernal outcomeperinatal complication |
| spellingShingle | Liangmiao Chen Liangmiao Chen Hong Yang Enling Ye Zhenzhen Lin Mengmeng Peng Hai Lin Lechu Yu Zhuhua Cai Xuemian Lu Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy Frontiers in Endocrinology isolated hypothyroxinemia first trimester second trimester pregnancy outcome maternal outcome perinatal complication |
| title | Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy |
| title_full | Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy |
| title_fullStr | Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy |
| title_full_unstemmed | Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy |
| title_short | Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy |
| title_sort | insignificant effect of isolated hypothyroxinemia on pregnancy outcomes during the first and second trimester of pregnancy |
| topic | isolated hypothyroxinemia first trimester second trimester pregnancy outcome maternal outcome perinatal complication |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.528146/full |
| work_keys_str_mv | AT liangmiaochen insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT liangmiaochen insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT hongyang insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT enlingye insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT zhenzhenlin insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT mengmengpeng insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT hailin insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT lechuyu insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT zhuhuacai insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy AT xuemianlu insignificanteffectofisolatedhypothyroxinemiaonpregnancyoutcomesduringthefirstandsecondtrimesterofpregnancy |