Major genes affecting ovulation rate in sheep
<p>Abstract</p> <p>Research conducted since 1980 in relation to inheritance patterns and DNA testing of major genes for prolificacy has shown that major genes have the potential to significantly increase the reproductive performance of sheep flocks throughout the world. Mutations t...
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| Format: | Article |
| Language: | deu |
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BMC
2005-12-01
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| Series: | Genetics Selection Evolution |
| Subjects: | |
| Online Access: | http://www.gsejournal.org/content/37/S1/S11 |
| _version_ | 1811281257591472128 |
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| author | Davis George |
| author_facet | Davis George |
| author_sort | Davis George |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Research conducted since 1980 in relation to inheritance patterns and DNA testing of major genes for prolificacy has shown that major genes have the potential to significantly increase the reproductive performance of sheep flocks throughout the world. Mutations that increase ovulation rate have been discovered in the <it>BMPR-1B</it>, <it>BMP15 </it>and <it>GDF9 </it>genes, and others are known to exist from the expressed inheritance patterns although the mutations have not yet been located. In the case of <it>BMP15</it>, four different mutations have been discovered but each produces the same phenotype. The modes of inheritance of the different prolificacy genes include autosomal dominant genes with additive effects on ovulation rate (<it>BMPR-1B</it>; <it>Lacaune</it>), autosomal over-dominant genes with infertility in homozygous females (<it>GDF9</it>), X-linked over-dominant genes with infertility in homozygous females (<it>BMP15</it>), and X-linked maternally imprinted genes (<it>FecX2</it>). The size of the effect of one copy of a mutation on ovulation rate ranges from an extra 0.4 ovulations per oestrus for the <it>FecX2 </it>mutation to an extra 1.5 ovulations per oestrus for the <it>BMPR-1B </it>mutation. A commercial DNA testing service enables some of these mutations to be used in genetic improvement programmes based on marker assisted selection.</p> |
| first_indexed | 2024-04-13T01:29:15Z |
| format | Article |
| id | doaj.art-f43656152b2447f3b04d09a416298ef4 |
| institution | Directory Open Access Journal |
| issn | 0999-193X 1297-9686 |
| language | deu |
| last_indexed | 2024-04-13T01:29:15Z |
| publishDate | 2005-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Genetics Selection Evolution |
| spelling | doaj.art-f43656152b2447f3b04d09a416298ef42022-12-22T03:08:33ZdeuBMCGenetics Selection Evolution0999-193X1297-96862005-12-0137Suppl 1S11S2310.1186/1297-9686-37-S1-S11Major genes affecting ovulation rate in sheepDavis George<p>Abstract</p> <p>Research conducted since 1980 in relation to inheritance patterns and DNA testing of major genes for prolificacy has shown that major genes have the potential to significantly increase the reproductive performance of sheep flocks throughout the world. Mutations that increase ovulation rate have been discovered in the <it>BMPR-1B</it>, <it>BMP15 </it>and <it>GDF9 </it>genes, and others are known to exist from the expressed inheritance patterns although the mutations have not yet been located. In the case of <it>BMP15</it>, four different mutations have been discovered but each produces the same phenotype. The modes of inheritance of the different prolificacy genes include autosomal dominant genes with additive effects on ovulation rate (<it>BMPR-1B</it>; <it>Lacaune</it>), autosomal over-dominant genes with infertility in homozygous females (<it>GDF9</it>), X-linked over-dominant genes with infertility in homozygous females (<it>BMP15</it>), and X-linked maternally imprinted genes (<it>FecX2</it>). The size of the effect of one copy of a mutation on ovulation rate ranges from an extra 0.4 ovulations per oestrus for the <it>FecX2 </it>mutation to an extra 1.5 ovulations per oestrus for the <it>BMPR-1B </it>mutation. A commercial DNA testing service enables some of these mutations to be used in genetic improvement programmes based on marker assisted selection.</p>http://www.gsejournal.org/content/37/S1/S11major geneovulation ratesheepreproduction |
| spellingShingle | Davis George Major genes affecting ovulation rate in sheep Genetics Selection Evolution major gene ovulation rate sheep reproduction |
| title | Major genes affecting ovulation rate in sheep |
| title_full | Major genes affecting ovulation rate in sheep |
| title_fullStr | Major genes affecting ovulation rate in sheep |
| title_full_unstemmed | Major genes affecting ovulation rate in sheep |
| title_short | Major genes affecting ovulation rate in sheep |
| title_sort | major genes affecting ovulation rate in sheep |
| topic | major gene ovulation rate sheep reproduction |
| url | http://www.gsejournal.org/content/37/S1/S11 |
| work_keys_str_mv | AT davisgeorge majorgenesaffectingovulationrateinsheep |