Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

Summary: We report robust SARS-CoV2 neutralizing sdAbs targeting the viral peptides encompassing the polybasic cleavage site (CSP) and in the receptor binding domain (RBD) of the spike (S) protein. Both the sdAbs inhibited infectivity of the CoV2 S protein expressing pseudoviruses (LV-CoV2S). Both a...

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Bibliographic Details
Main Authors: Sudhakar Singh, Surbhi Dahiya, Yuviana J. Singh, Komal Beeton, Ayush Jain, Roman Sarkar, Abhishek Dubey, Azeez Tehseen, Sharvan Sehrawat
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Virology
Immunology, and Drugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008215

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