Catechins as Tools to Understand the Molecular Basis of Neurodegeneration
Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the u...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/16/3571 |
| _version_ | 1827711423881412608 |
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| author | Karla Martinez Pomier Rashik Ahmed Giuseppe Melacini |
| author_facet | Karla Martinez Pomier Rashik Ahmed Giuseppe Melacini |
| author_sort | Karla Martinez Pomier |
| collection | DOAJ |
| description | Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the underlying molecular mechanisms and may offer insight on potential therapeutic solutions. These modulators include green tea catechins, which are potent inhibitors of amyloid aggregation. Although catechins often exhibit poor pharmacokinetic properties and bioavailability, they are still essential tools for identifying the drivers of amyloid aggregation and for developing other aggregation modulators through structural mimicry. As an illustration of such strategies, here we review how catechins have been used to map the toxic surfaces of oligomeric amyloid-like species and develop catechin-based phenolic compounds with enhanced anti-amyloid activity. |
| first_indexed | 2024-03-10T17:54:24Z |
| format | Article |
| id | doaj.art-f43999d6613e4273af7b4fde45369c76 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T17:54:24Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f43999d6613e4273af7b4fde45369c762023-11-20T09:15:56ZengMDPI AGMolecules1420-30492020-08-012516357110.3390/molecules25163571Catechins as Tools to Understand the Molecular Basis of NeurodegenerationKarla Martinez Pomier0Rashik Ahmed1Giuseppe Melacini2Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, CanadaDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4M1, CanadaDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4M1, CanadaProtein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the underlying molecular mechanisms and may offer insight on potential therapeutic solutions. These modulators include green tea catechins, which are potent inhibitors of amyloid aggregation. Although catechins often exhibit poor pharmacokinetic properties and bioavailability, they are still essential tools for identifying the drivers of amyloid aggregation and for developing other aggregation modulators through structural mimicry. As an illustration of such strategies, here we review how catechins have been used to map the toxic surfaces of oligomeric amyloid-like species and develop catechin-based phenolic compounds with enhanced anti-amyloid activity.https://www.mdpi.com/1420-3049/25/16/3571Alzheimer’s Diseaseamyloid betacatechinEGCGNMRα-synuclein |
| spellingShingle | Karla Martinez Pomier Rashik Ahmed Giuseppe Melacini Catechins as Tools to Understand the Molecular Basis of Neurodegeneration Molecules Alzheimer’s Disease amyloid beta catechin EGCG NMR α-synuclein |
| title | Catechins as Tools to Understand the Molecular Basis of Neurodegeneration |
| title_full | Catechins as Tools to Understand the Molecular Basis of Neurodegeneration |
| title_fullStr | Catechins as Tools to Understand the Molecular Basis of Neurodegeneration |
| title_full_unstemmed | Catechins as Tools to Understand the Molecular Basis of Neurodegeneration |
| title_short | Catechins as Tools to Understand the Molecular Basis of Neurodegeneration |
| title_sort | catechins as tools to understand the molecular basis of neurodegeneration |
| topic | Alzheimer’s Disease amyloid beta catechin EGCG NMR α-synuclein |
| url | https://www.mdpi.com/1420-3049/25/16/3571 |
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