GPCR structural characterization by NMR spectroscopy in solution

GPCR structural characterization by NMR spectroscopy in solution

In the human proteome, 826 G-protein-coupled receptors (GPCRs) interact with extracellular stimuli to initiate cascades of intracellular signaling. Determining conformational dynamics and intermolecular interactions are key to understand GPCR function as a basis for drug design. X-ray crystallograph...

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Bibliographic Details
Main Authors: Yang Lingyun, Liu Dongsheng, Wüthrich Kurt
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-08-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
G protein-coupled receptor dynamics
stable-isotope labeling
fluorine-19 NMR
GPCR biology
drug development
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022106

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