β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

Abstract The β2-Adrenergic receptor (β2-ARs) is a cell membrane-spanning G protein-coupled receptors (GPCRs) physiologically involved in stress-related response. In many cancers, the β2-ARs signaling drives the tumor development and transformation, also promoting the resistance to the treatments. In...

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Bibliographic Details
Main Authors: Vitale Del Vecchio, Luigi Mele, Sameer Kumar Panda, Ibone Rubio Sanchez-Pajares, Laura Mosca, Virginia Tirino, Massimiliano Barbieri, Francesca Bruzzese, Antonio Luciano, Federica Zito Marino, Marina Accardo, Giovanni Francesco Nicoletti, Gianpaolo Papaccio, Antonio Barbieri, Vincenzo Desiderio
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06129-9

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