IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia

IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia

Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm birth survivors characterized by inflammation, impaired alveolarization and dysmorphic vasculature. Activated IL-17A+ lymphocytes are key drivers of inflammation in preterm infants. We have shown that in immature mice chronic airw...

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Bibliographic Details
Main Authors: Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Chase Anderson, Antonia P. Popova
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
bronchopulmonary dysplasia (BPD)
IL-17A
NKG2D
gamma delta T cells
inflammation
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1156842/full

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