Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients
Background: Vitamin D (Vit D) deficiency is a common disorder in diabetic patients and may be a risk factor for ischemic heart disease and exacerbation of diabetic nephropathy(DN). Objectives: The aim of this study was to evaluate the effect of Vit D3 therapy on protein uriain type 2 diabetic patien...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2017-01-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/JNP-6-10.pdf |
| _version_ | 1827948587740299264 |
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| author | Ali Momeni Mahmood Mirhosseini Mohsen Kabiri Soleiman Kheiri |
| author_facet | Ali Momeni Mahmood Mirhosseini Mohsen Kabiri Soleiman Kheiri |
| author_sort | Ali Momeni |
| collection | DOAJ |
| description | Background: Vitamin D (Vit D) deficiency is a common disorder in diabetic patients and may be a risk factor for ischemic heart disease and exacerbation of diabetic nephropathy(DN). Objectives: The aim of this study was to evaluate the effect of Vit D3 therapy on protein uriain type 2 diabetic patients with deficient or insufficient serum Vit D. Patients and Methods: In a double blind clinical trial, 60 type 2 diabetic patients with proteinuria greater than 150 mg/day who had Vit D deficiency or insufficiency were randomly enrolled in two equal groups. Pearl of Vit D as 50 000 IU/week and placebo (1 tablet per week) were prescribed in patients of case and control groups respectively for 8 weeks. At the beginning and 2 months later, 24 hours urine protein was checked in all patients. Results: There is no difference between serums Vit D level in case and control group at the beginning of the study, however at the end of the study serum Vit D level was significantly higher in the case group. There is no difference in proteinuria between case and control group at the beginning and the end of the study, while a significant difference between the changes of proteinuria before and after the study was seen in two groups (P = 0.028). Conclusions: Vit D deficiency may exacerbate protein uric and DN, hence correction of Vit D deficiency may decrease proteinuria in diabetic patients with nephropathy. |
| first_indexed | 2024-04-09T12:57:42Z |
| format | Article |
| id | doaj.art-f43cce48ada5460a89e2da79ffb0f3d5 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:42Z |
| publishDate | 2017-01-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-f43cce48ada5460a89e2da79ffb0f3d52023-05-13T11:31:52ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192017-01-0161101410.15171/jnp.2017.03JNP_20161009155930Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patientsAli Momeni0Mahmood Mirhosseini1Mohsen Kabiri2Soleiman Kheiri3Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranSocial Health Determinants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranBackground: Vitamin D (Vit D) deficiency is a common disorder in diabetic patients and may be a risk factor for ischemic heart disease and exacerbation of diabetic nephropathy(DN). Objectives: The aim of this study was to evaluate the effect of Vit D3 therapy on protein uriain type 2 diabetic patients with deficient or insufficient serum Vit D. Patients and Methods: In a double blind clinical trial, 60 type 2 diabetic patients with proteinuria greater than 150 mg/day who had Vit D deficiency or insufficiency were randomly enrolled in two equal groups. Pearl of Vit D as 50 000 IU/week and placebo (1 tablet per week) were prescribed in patients of case and control groups respectively for 8 weeks. At the beginning and 2 months later, 24 hours urine protein was checked in all patients. Results: There is no difference between serums Vit D level in case and control group at the beginning of the study, however at the end of the study serum Vit D level was significantly higher in the case group. There is no difference in proteinuria between case and control group at the beginning and the end of the study, while a significant difference between the changes of proteinuria before and after the study was seen in two groups (P = 0.028). Conclusions: Vit D deficiency may exacerbate protein uric and DN, hence correction of Vit D deficiency may decrease proteinuria in diabetic patients with nephropathy.https://nephropathol.com/PDF/JNP-6-10.pdfvitamin ddiabetes mellitusproteinuriadiabetic nephropathy |
| spellingShingle | Ali Momeni Mahmood Mirhosseini Mohsen Kabiri Soleiman Kheiri Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients Journal of Nephropathology vitamin d diabetes mellitus proteinuria diabetic nephropathy |
| title | Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients |
| title_full | Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients |
| title_fullStr | Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients |
| title_full_unstemmed | Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients |
| title_short | Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients |
| title_sort | impact of vitamin d therapy on decreasing of proteinuria in type 2 diabetic patients |
| topic | vitamin d diabetes mellitus proteinuria diabetic nephropathy |
| url | https://nephropathol.com/PDF/JNP-6-10.pdf |
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