Application of photoacoustic computed tomography in biomedical imaging: A literature review
Abstract Photoacoustic computed tomography (PACT) is a hybrid imaging modality that combines optical excitation and acoustic detection techniques. It obtains high‐resolution deep‐tissue images based on the deep penetration of light, the anisotropy of light absorption in objects, and the photoacousti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Bioengineering & Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/btm2.10419 |
| _version_ | 1797870976443088896 |
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| author | Yanru Gu Yuanyuan Sun Xiao Wang Hongyu Li Jianfeng Qiu Weizhao Lu |
| author_facet | Yanru Gu Yuanyuan Sun Xiao Wang Hongyu Li Jianfeng Qiu Weizhao Lu |
| author_sort | Yanru Gu |
| collection | DOAJ |
| description | Abstract Photoacoustic computed tomography (PACT) is a hybrid imaging modality that combines optical excitation and acoustic detection techniques. It obtains high‐resolution deep‐tissue images based on the deep penetration of light, the anisotropy of light absorption in objects, and the photoacoustic effect. Hence, PACT shows great potential in biomedical sample imaging. Recently, due to its advantages of high sensitivity to optical absorption and wide scalability of spatial resolution with the desired imaging depth, PACT has received increasing attention in preclinical and clinical practice. To date, there has been a proliferation of PACT systems designed for specific biomedical imaging applications, from small animals to human organs, from ex vivo to in vivo real‐time imaging, and from simple structural imaging to functional and molecular imaging with external contrast agents. Therefore, it is of great importance to summarize the previous applications of PACT systems in biomedical imaging and clinical practice. In this review, we searched for studies related to PACT imaging of biomedical tissues and samples over the past two decades; divided the studies into two categories, PACT imaging of preclinical animals and PACT imaging of human organs and body parts; and discussed the significance of the studies. Finally, we pointed out the future directions of PACT in biomedical applications. With the development of exogenous contrast agents and advances of imaging technique, in the future, PACT will enable biomedical imaging from organs to whole bodies, from superficial vasculature to internal organs, from anatomy to functions, and will play an increasingly important role in biomedical research and clinical practice. |
| first_indexed | 2024-04-10T00:36:57Z |
| format | Article |
| id | doaj.art-f43d9193e6f147e09a0400aeade9b5ca |
| institution | Directory Open Access Journal |
| issn | 2380-6761 |
| language | English |
| last_indexed | 2024-04-10T00:36:57Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj.art-f43d9193e6f147e09a0400aeade9b5ca2023-03-14T16:53:48ZengWileyBioengineering & Translational Medicine2380-67612023-03-0182n/an/a10.1002/btm2.10419Application of photoacoustic computed tomography in biomedical imaging: A literature reviewYanru Gu0Yuanyuan Sun1Xiao Wang2Hongyu Li3Jianfeng Qiu4Weizhao Lu5Department of Radiology The Second Affiliated Hospital of Shandong First Medical University Taian ChinaDepartment of Radiology Shandong First Medical University and Shandong Academy of Medical Sciences Taian ChinaCollege of Ocean Science and Engineering Shandong University of Science and Technology Qingdao ChinaCollege of Ocean Science and Engineering Shandong University of Science and Technology Qingdao ChinaDepartment of Radiology Shandong First Medical University and Shandong Academy of Medical Sciences Taian ChinaDepartment of Radiology The Second Affiliated Hospital of Shandong First Medical University Taian ChinaAbstract Photoacoustic computed tomography (PACT) is a hybrid imaging modality that combines optical excitation and acoustic detection techniques. It obtains high‐resolution deep‐tissue images based on the deep penetration of light, the anisotropy of light absorption in objects, and the photoacoustic effect. Hence, PACT shows great potential in biomedical sample imaging. Recently, due to its advantages of high sensitivity to optical absorption and wide scalability of spatial resolution with the desired imaging depth, PACT has received increasing attention in preclinical and clinical practice. To date, there has been a proliferation of PACT systems designed for specific biomedical imaging applications, from small animals to human organs, from ex vivo to in vivo real‐time imaging, and from simple structural imaging to functional and molecular imaging with external contrast agents. Therefore, it is of great importance to summarize the previous applications of PACT systems in biomedical imaging and clinical practice. In this review, we searched for studies related to PACT imaging of biomedical tissues and samples over the past two decades; divided the studies into two categories, PACT imaging of preclinical animals and PACT imaging of human organs and body parts; and discussed the significance of the studies. Finally, we pointed out the future directions of PACT in biomedical applications. With the development of exogenous contrast agents and advances of imaging technique, in the future, PACT will enable biomedical imaging from organs to whole bodies, from superficial vasculature to internal organs, from anatomy to functions, and will play an increasingly important role in biomedical research and clinical practice.https://doi.org/10.1002/btm2.10419animalsbiomedical imaginghumansphotoacoustic computed tomography |
| spellingShingle | Yanru Gu Yuanyuan Sun Xiao Wang Hongyu Li Jianfeng Qiu Weizhao Lu Application of photoacoustic computed tomography in biomedical imaging: A literature review Bioengineering & Translational Medicine animals biomedical imaging humans photoacoustic computed tomography |
| title | Application of photoacoustic computed tomography in biomedical imaging: A literature review |
| title_full | Application of photoacoustic computed tomography in biomedical imaging: A literature review |
| title_fullStr | Application of photoacoustic computed tomography in biomedical imaging: A literature review |
| title_full_unstemmed | Application of photoacoustic computed tomography in biomedical imaging: A literature review |
| title_short | Application of photoacoustic computed tomography in biomedical imaging: A literature review |
| title_sort | application of photoacoustic computed tomography in biomedical imaging a literature review |
| topic | animals biomedical imaging humans photoacoustic computed tomography |
| url | https://doi.org/10.1002/btm2.10419 |
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