FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability

FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability

Abstract Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder emerging in early life characterized by impairments in social interaction, poor verbal and non-verbal communication, and repetitive patterns of behaviors. Among the best-known genetic risk factors for ASD, there are m...

Full description

Bibliographic Details
Main Authors:	Annunziata D’Elia, Sara Schiavi, Antonia Manduca, Alessandro Rava, Valeria Buzzelli, Fabrizio Ascone, Tiziana Orsini, Sabrina Putti, Andrea Soluri, Filippo Galli, Alessandro Soluri, Maurizio Mattei, Rosella Cicconi, Roberto Massari, Viviana Trezza
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-12-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-26986-2

Similar Items

Maternal Immune Activation Induced by Prenatal Lipopolysaccharide Exposure Leads to Long-Lasting Autistic-like Social, Cognitive and Immune Alterations in Male Wistar Rats
by: Emilia Carbone, et al.
Published: (2023-02-01)

Bananas Before Plantations. Smallholders, Shippers, and Colonial Policy in Jamaica, 1870-1910
by: John Soluri
Published: (2014-06-01)

Striatal glutamatergic hyperactivity in Parkinson's disease
by: F. Campanelli, et al.
Published: (2022-06-01)

Cortical control of striatal dopamine transmission via striatal cholinergic interneurons
by: Kosillo, P, et al.
Published: (2016)

Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors
by: Antonia Manduca, et al.
Published: (2024-05-01)

Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy
by: Alessandro Rava, et al.
Published: (2023-03-01)

Investigating the presynaptic control of striatal dopamine release
by: Platt, N, et al.
Published: (2012)

Striatal dopamine neurotransmission: regulation of release and uptake
by: Sulzer, D, et al.
Published: (2016)

Endocannabinoid-dopamine interactions in striatal synaptic plasticity
by: Brian Neil Mathur, et al.
Published: (2012-04-01)

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
by: Condon, MD, et al.
Published: (2019)

Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding
by: Speed, Nicole, et al.
Published: (2013)

Striatal acetylcholine control of reward-related dopamine signalling
by: Cragg, S, et al.
Published: (2005)

On the normative advantages of dopamine and striatal opponency for learning and choice
by: Alana Jaskir, et al.
Published: (2023-03-01)

Investigating the control of striatal dopamine neurotransmission by axonal calcium channels and by striatal neuromodulators: Insights for Parkinson's disease
by: Brimblecombe, K, et al.
Published: (2014)

Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder
by: Gauri G. Shastri, et al.
Published: (2024-04-01)

Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.
by: Threlfell, S, et al.
Published: (2012)

Striatal and limbic dopamine function: evidence from animal studies.
by: Alpert, J, et al.
Published: (1983)

Electrophysiological properties of striatal neurons in the dopamine-intact and Parkinsonian brain
by: Vinciati, F
Published: (2015)

Elevated striatal dopamine function linked to prodromal signs of schizophrenia.
by: Howes, O, et al.
Published: (2009)

Regulation of dopamine release by striatal GABA and acetylcholine in health and disease
by: Lopes, EF
Published: (2019)

Inhibition of nigrostriatal dopamine release by striatal GABAA and GABAB receptors
by: Lopes, E, et al.
Published: (2018)

Dopamine lesions alter the striatal encoding of single-limb gait
by: Long Yang, et al.
Published: (2024-03-01)

Striatal dopamine release tracks the relationship between actions and their consequences
by: G. Hart, et al.
Published: (2024-03-01)

Local and global consequences of reward-evoked striatal dopamine release
by: Li, Nan, et al.
Published: (2021)

Changes in striatal dopamine transporters in bipolar disorder and valproate treatment
by: Yuan-Shuo Hsueh, et al.
Published: (2021-01-01)

Concept, development and evaluation of a mind action game with the electro encephalograms as an auxiliary input
by: Mark Joselli, et al.
Published: (2017-09-01)

Striatal GABA transporter regulation of dopamine release and dysfunction in Parkinsonian models
by: Roberts, BM
Published: (2019)

Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
by: Hillary A. Wadsworth, et al.
Published: (2024-04-01)

The Influence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-depleted Rats
by: Dmitry Voronkov, et al.
Published: (2021-11-01)

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes
by: Sarah Amato, et al.
Published: (2023-02-01)

Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
by: Allen P. F. Chen, et al.
Published: (2023-11-01)

Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease
by: Jae Jung Lee, et al.
Published: (2015-09-01)

Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding
by: Bonocora, Richard P., et al.
Published: (2012)

Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release
by: Aditi Banerjee, et al.
Published: (2020-06-01)

Mechanisms for the modulation of dopamine D1 receptor signaling in striatal neurons
by: Akinori eNishi, et al.
Published: (2011-07-01)

Corrigendum: Striatal dopamine D2-muscarinic acetylcholine M1 receptor-receptor interaction in a model of movement disorders
by: René A. J. Crans, et al.
Published: (2022-11-01)

Sex Differences in Dopamine Receptor Signaling in <i>Fmr1</i> Knockout Mice: A Pilot Study
by: Anlong Jiang, et al.
Published: (2021-10-01)

Responsivity of the Striatal Dopamine System to Methylphenidate—A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
by: Hans-Christoph Aster, et al.
Published: (2022-04-01)

Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor
by: Tatyana D. Sotnikova, et al.
Published: (2020-11-01)

Activation of the Rostral Intralaminar Thalamus drives reinforcement through Striatal Dopamine release
by: Cover, KK, et al.
Published: (2019)