H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation
Summary: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic inflammation is unknown. Here we show that following LPS...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719315256 |
| _version_ | 1818230644264665088 |
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| author | Orhan Rasid Christine Chevalier Tiphaine Marie-Noelle Camarasa Catherine Fitting Jean-Marc Cavaillon Melanie Anne Hamon |
| author_facet | Orhan Rasid Christine Chevalier Tiphaine Marie-Noelle Camarasa Catherine Fitting Jean-Marc Cavaillon Melanie Anne Hamon |
| author_sort | Orhan Rasid |
| collection | DOAJ |
| description | Summary: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic inflammation is unknown. Here we show that following LPS-induced endotoxemia in mice, NK cells acquire cell-intrinsic memory-like properties, showing increased production of IFNγ upon specific secondary stimulation. The NK cell memory response is detectable for at least 9 weeks and contributes to protection from E. coli infection upon adoptive transfer. Importantly, we reveal a mechanism essential for NK cell memory, whereby an H3K4me1-marked latent enhancer is uncovered at the ifng locus. Chemical inhibition of histone methyltransferase activity erases the enhancer and abolishes NK cell memory. Thus, NK cell memory develops after endotoxemia in a histone methylation-dependent manner, ensuring a heightened response to secondary stimulation. : Rasid et al. show that sepsis-like systemic inflammation induces a type of long-lasting innate immune memory in NK cells, which can protect from E. coli infection. This is achieved by revealing an enhancer of IFNγ through histone monomethylation. Keywords: NK cells, NK cell memory, sepsis, epigenetic, H3K4me1 |
| first_indexed | 2024-12-12T10:37:46Z |
| format | Article |
| id | doaj.art-f43df46125154cb4a2112aa02b25e9ca |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T10:37:46Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-f43df46125154cb4a2112aa02b25e9ca2022-12-22T00:27:10ZengElsevierCell Reports2211-12472019-12-01291239333945.e3H3K4me1 Supports Memory-like NK Cells Induced by Systemic InflammationOrhan Rasid0Christine Chevalier1Tiphaine Marie-Noelle Camarasa2Catherine Fitting3Jean-Marc Cavaillon4Melanie Anne Hamon5G5 Chromatine et Infection, Institut Pasteur, Paris, France; Unité Cytokines & Inflammation, Institut Pasteur, Paris, France; Corresponding authorG5 Chromatine et Infection, Institut Pasteur, Paris, FranceG5 Chromatine et Infection, Institut Pasteur, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, FranceUnité Cytokines & Inflammation, Institut Pasteur, Paris, FranceUnité Cytokines & Inflammation, Institut Pasteur, Paris, FranceG5 Chromatine et Infection, Institut Pasteur, Paris, France; Corresponding authorSummary: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic inflammation is unknown. Here we show that following LPS-induced endotoxemia in mice, NK cells acquire cell-intrinsic memory-like properties, showing increased production of IFNγ upon specific secondary stimulation. The NK cell memory response is detectable for at least 9 weeks and contributes to protection from E. coli infection upon adoptive transfer. Importantly, we reveal a mechanism essential for NK cell memory, whereby an H3K4me1-marked latent enhancer is uncovered at the ifng locus. Chemical inhibition of histone methyltransferase activity erases the enhancer and abolishes NK cell memory. Thus, NK cell memory develops after endotoxemia in a histone methylation-dependent manner, ensuring a heightened response to secondary stimulation. : Rasid et al. show that sepsis-like systemic inflammation induces a type of long-lasting innate immune memory in NK cells, which can protect from E. coli infection. This is achieved by revealing an enhancer of IFNγ through histone monomethylation. Keywords: NK cells, NK cell memory, sepsis, epigenetic, H3K4me1http://www.sciencedirect.com/science/article/pii/S2211124719315256 |
| spellingShingle | Orhan Rasid Christine Chevalier Tiphaine Marie-Noelle Camarasa Catherine Fitting Jean-Marc Cavaillon Melanie Anne Hamon H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation Cell Reports |
| title | H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation |
| title_full | H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation |
| title_fullStr | H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation |
| title_full_unstemmed | H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation |
| title_short | H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation |
| title_sort | h3k4me1 supports memory like nk cells induced by systemic inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719315256 |
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