Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism

Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism

Background/Purpose: Severe acute respiratory syndrome coronavirus (SARS-CoV) proteins including ORF6 inhibit Type I interferon (IFN) signaling. Methods: This study identified SARS-CoV ORF6-interacting proteins using the phage displayed human lung cDNA libraries, and examined the association of ORF6–...

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Bibliographic Details
Main Authors: Su-Hua Huang, Tzu-Ying Lee, Ying-Ju Lin, Lei Wan, Chih-Ho Lai, Cheng-Wen Lin
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Microbiology, Immunology and Infection
Subjects:
IFN antagonism
NPIPB3
ORF6
phage display
SARS-CoV
Online Access:http://www.sciencedirect.com/science/article/pii/S1684118215008051

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