Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
ObjectivesFew epidemiological studies have studied the effect of 2,3,7,8-tetrachlorodibenzo-p dioxin (TCDD) on blood cytokine levels. In this study we investigated changes in plasma levels of a large panel of cytokines, chemokines and growth factors among workers from a Dutch historical cohort occup...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00037/full |
| _version_ | 1811235701617852416 |
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| author | Fatemeh eSaberi Hosnijeh Fatemeh eSaberi Hosnijeh Daisy eBoers Lützen ePortengen Bas eBueno De Mesquita Bas eBueno De Mesquita Dick eHeederik Roel eVermeulen Roel eVermeulen |
| author_facet | Fatemeh eSaberi Hosnijeh Fatemeh eSaberi Hosnijeh Daisy eBoers Lützen ePortengen Bas eBueno De Mesquita Bas eBueno De Mesquita Dick eHeederik Roel eVermeulen Roel eVermeulen |
| author_sort | Fatemeh eSaberi Hosnijeh |
| collection | DOAJ |
| description | ObjectivesFew epidemiological studies have studied the effect of 2,3,7,8-tetrachlorodibenzo-p dioxin (TCDD) on blood cytokine levels. In this study we investigated changes in plasma levels of a large panel of cytokines, chemokines and growth factors among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD.MethodsEighty-five workers who had been exposed to either high (n=47) or low (n=38) TCDD levels more than 30 years before serum collection were included in the current investigation. Plasma level of 16 cytokines, 10 chemokines and 6 growth factors were measured. Current plasma levels of TCDD (TCDDCurrent) were determined by high resolution gas chromatography/isotope dilution high resolution mass spectrometry. TCDD blood levels at the time of last exposure (TCDDmax) were estimated using a one-compartment first order kinetic model. ResultsBlood levels of most analytes had a negative association with current and estimated past maximum TCDD levels. These decreases reached formal statistical significance for fractalkine, transforming growth factor alpha (TGF-α) and fibroblast growth factor 2 (FGF2) with increasing TCDD levels.ConclusionsOur study showed a general reduction in most analyte levels with the strongest effects for fractalkine, FGF2 and TGF-α. These findings suggest that TCDD exposure could suppress the immune system and that chemokine and growth factor-dependent cellular pathway changes by TCDD may play role in TCDD toxicity and associated health effects. |
| first_indexed | 2024-04-12T11:56:29Z |
| format | Article |
| id | doaj.art-f43e8eb6edaa41a18c4c36d7f21e1af7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T11:56:29Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f43e8eb6edaa41a18c4c36d7f21e1af72022-12-22T03:33:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2012-04-01210.3389/fonc.2012.0003721318Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)Fatemeh eSaberi Hosnijeh0Fatemeh eSaberi Hosnijeh1Daisy eBoers2Lützen ePortengen3Bas eBueno De Mesquita4Bas eBueno De Mesquita5Dick eHeederik6Roel eVermeulen7Roel eVermeulen8Utrecht UniversityZanjan Medical UniversityUtrecht UniversityUtrecht UniversityNational institute for public health and environment (RIVM)University Medical Center UtrechtUtrecht UniversityUtrecht UniversityUtrecht UniversityObjectivesFew epidemiological studies have studied the effect of 2,3,7,8-tetrachlorodibenzo-p dioxin (TCDD) on blood cytokine levels. In this study we investigated changes in plasma levels of a large panel of cytokines, chemokines and growth factors among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD.MethodsEighty-five workers who had been exposed to either high (n=47) or low (n=38) TCDD levels more than 30 years before serum collection were included in the current investigation. Plasma level of 16 cytokines, 10 chemokines and 6 growth factors were measured. Current plasma levels of TCDD (TCDDCurrent) were determined by high resolution gas chromatography/isotope dilution high resolution mass spectrometry. TCDD blood levels at the time of last exposure (TCDDmax) were estimated using a one-compartment first order kinetic model. ResultsBlood levels of most analytes had a negative association with current and estimated past maximum TCDD levels. These decreases reached formal statistical significance for fractalkine, transforming growth factor alpha (TGF-α) and fibroblast growth factor 2 (FGF2) with increasing TCDD levels.ConclusionsOur study showed a general reduction in most analyte levels with the strongest effects for fractalkine, FGF2 and TGF-α. These findings suggest that TCDD exposure could suppress the immune system and that chemokine and growth factor-dependent cellular pathway changes by TCDD may play role in TCDD toxicity and associated health effects.http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00037/fullchemokinecytokinedioxingrowth factorNHLTCDD |
| spellingShingle | Fatemeh eSaberi Hosnijeh Fatemeh eSaberi Hosnijeh Daisy eBoers Lützen ePortengen Bas eBueno De Mesquita Bas eBueno De Mesquita Dick eHeederik Roel eVermeulen Roel eVermeulen Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Frontiers in Oncology chemokine cytokine dioxin growth factor NHL TCDD |
| title | Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| title_full | Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| title_fullStr | Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| title_full_unstemmed | Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| title_short | Plasma cytokine concentrations in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| title_sort | plasma cytokine concentrations in workers exposed to 2 3 7 8 tetrachlorodibenzo p dioxin tcdd |
| topic | chemokine cytokine dioxin growth factor NHL TCDD |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00037/full |
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