Novel 2,6,9-Trisubstituted Purines as Potent CDK Inhibitors Alleviating Trastuzumab-Resistance of HER2-Positive Breast Cancers
HER2-positive (HER2+) breast cancer is defined by <i>HER2</i> oncogene amplification on chromosome 17q12 and accounts for 15–20% population of breast-cancer patients. Therapeutic anti-HER2 antibody such as trastuzumab is used as the first-line therapy for HER2-positive breast cancers. Ho...
Main Authors: | Ratnakar Reddy Kuchukulla, Injeoung Hwang, Sang Won Park, Sojeong Moon, Suhn Hyung Kim, Sumin Kim, Hwan Won Chung, Mi-Jung Ji, Hyun-Mee Park, Gu Kong, Wooyoung Hur |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-08-01
|
Series: | Pharmaceuticals |
Subjects: | |
Online Access: | https://www.mdpi.com/1424-8247/15/9/1041 |
Similar Items
-
Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity
by: Michal Rouchal, et al.
Published: (2021-11-01) -
Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors
by: Monika Tomanová, et al.
Published: (2022-12-01) -
Mammaglobin 1 mediates progression of trastuzumab‐resistant breast cancer cells through regulation of cyclins and NF‐κB
by: Ratih Kusumastuti, et al.
Published: (2022-10-01) -
rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome
by: Hyein Jeong, et al.
Published: (2021-03-01) -
Florida Darkwinged Subterranean Termite, Amitermes floridensis Scheffrahn, Su, and Mangold (Insecta: Isoptera: Termitidae: Termitinae)
by: Rudolf H. Scheffrahn, et al.
Published: (2002-11-01)