Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments

Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments

Abstract The alphaherpesvirus pseudorabies virus (PRV) is the causative agent of pseudorabies, responsible for severe economic losses to the swine industry worldwide. The interferon-inducible GTPase guanylate-binding protein 1 (GBP1) exhibits antiviral immunity. Our findings show that there is a rob...

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Bibliographic Details
Main Authors: Xiaohua Zhang, Qian Du, Guiyuan Chen, Yiyuan Jiang, Kai Huang, Linghao Li, Dewen Tong, Yong Huang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Veterinary Research
Subjects:
Pseudorabies virus (PRV)
GBP1
GTPase activity
serine/threonine protein kinase US3
actin filaments
Online Access:https://doi.org/10.1186/s13567-023-01154-0

Internet

https://doi.org/10.1186/s13567-023-01154-0

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