Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications
Oocyte donation (OD) has greatly improved over the last three decades, becoming a preferred practice of assisted reproductive technology (ART) for infertile women wishing for motherhood. Through OD, indeed, it has become possible to overcome the physiological limitation due to the ovarian reserve (O...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/18/13945 |
| _version_ | 1797579776031981568 |
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| author | Erica Silvestris Easter Anna Petracca Michele Mongelli Francesca Arezzo Vera Loizzi Maria Gaetani Pierpaolo Nicolì Gianluca Raffaello Damiani Gennaro Cormio |
| author_facet | Erica Silvestris Easter Anna Petracca Michele Mongelli Francesca Arezzo Vera Loizzi Maria Gaetani Pierpaolo Nicolì Gianluca Raffaello Damiani Gennaro Cormio |
| author_sort | Erica Silvestris |
| collection | DOAJ |
| description | Oocyte donation (OD) has greatly improved over the last three decades, becoming a preferred practice of assisted reproductive technology (ART) for infertile women wishing for motherhood. Through OD, indeed, it has become possible to overcome the physiological limitation due to the ovarian reserve (OR) exhaustion as well as the poor gamete reliability which parallels the increasing age of women. However, despite the great scientific contribution related to the success of OD in the field of infertility, this practice seems to be associated with a higher rate of major risky events during pregnancy as recurrent miscarriage, infections and placental diseases including gestational hypertension, pre-eclampsia and post-partum hemorrhage, as well as several maternal–fetal complications due to gametes manipulation and immune system interaction. Here, we will revisit this questioned topic since a number of studies in the medical literature focus on the successful aspects of the OD procedure in terms of pregnancy rate without, however, neglecting the risks and complications potentially linked to external manipulation or heterologous implantation. |
| first_indexed | 2024-03-10T22:40:48Z |
| format | Article |
| id | doaj.art-f442cc75f7e84a5ba4c15a2165ef0437 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:48Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f442cc75f7e84a5ba4c15a2165ef04372023-11-19T11:05:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181394510.3390/ijms241813945Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and ComplicationsErica Silvestris0Easter Anna Petracca1Michele Mongelli2Francesca Arezzo3Vera Loizzi4Maria Gaetani5Pierpaolo Nicolì6Gianluca Raffaello Damiani7Gennaro Cormio8Gynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyObstetrics and Gynecology Unit, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine (DIM), University of Bari “Aldo Moro”, 70121 Bari, ItalyGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyObstetrics and Gynecology Unit, University of Bari “Aldo Moro”, 70121 Bari, ItalyObstetrics and Gynecology Unit, University of Bari “Aldo Moro”, 70121 Bari, ItalyObstetrics and Gynecology Unit, University of Bari “Aldo Moro”, 70121 Bari, ItalyGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyOocyte donation (OD) has greatly improved over the last three decades, becoming a preferred practice of assisted reproductive technology (ART) for infertile women wishing for motherhood. Through OD, indeed, it has become possible to overcome the physiological limitation due to the ovarian reserve (OR) exhaustion as well as the poor gamete reliability which parallels the increasing age of women. However, despite the great scientific contribution related to the success of OD in the field of infertility, this practice seems to be associated with a higher rate of major risky events during pregnancy as recurrent miscarriage, infections and placental diseases including gestational hypertension, pre-eclampsia and post-partum hemorrhage, as well as several maternal–fetal complications due to gametes manipulation and immune system interaction. Here, we will revisit this questioned topic since a number of studies in the medical literature focus on the successful aspects of the OD procedure in terms of pregnancy rate without, however, neglecting the risks and complications potentially linked to external manipulation or heterologous implantation.https://www.mdpi.com/1422-0067/24/18/13945advanced techniquesassisted reproductive technologyinfertilityoocyte donationreproductive diseases |
| spellingShingle | Erica Silvestris Easter Anna Petracca Michele Mongelli Francesca Arezzo Vera Loizzi Maria Gaetani Pierpaolo Nicolì Gianluca Raffaello Damiani Gennaro Cormio Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications International Journal of Molecular Sciences advanced techniques assisted reproductive technology infertility oocyte donation reproductive diseases |
| title | Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications |
| title_full | Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications |
| title_fullStr | Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications |
| title_full_unstemmed | Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications |
| title_short | Pregnancy by Oocyte Donation: Reviewing Fetal–Maternal Risks and Complications |
| title_sort | pregnancy by oocyte donation reviewing fetal maternal risks and complications |
| topic | advanced techniques assisted reproductive technology infertility oocyte donation reproductive diseases |
| url | https://www.mdpi.com/1422-0067/24/18/13945 |
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