Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19
Multisystem inflammatory syndrome in children (MIS-C) is a novel syndrome in children following the coronavirus disease 2019 (COVID-19) pandemic, which has similar symptoms to Kawasaki disease or toxic shock syndrome. The most prevalent symptoms in MIS-C patients are fever and gastrointestinal sympt...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-03-01
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| Series: | Reviews in Clinical Medicine |
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| Online Access: | https://rcm.mums.ac.ir/article_22448_0e0e03a6f17532420a3f3443a619a561.pdf |
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| author | Behnaz Hatami Omid Shoraka Asef Younesi Gelayol Bavafa Melika Zamanian Niloofar Nikpasand Amirhossein Mohammadzade Sara Naghizadeh Kashani Anoush Azarfar Mojtaba Yousefi Zoshk |
| author_facet | Behnaz Hatami Omid Shoraka Asef Younesi Gelayol Bavafa Melika Zamanian Niloofar Nikpasand Amirhossein Mohammadzade Sara Naghizadeh Kashani Anoush Azarfar Mojtaba Yousefi Zoshk |
| author_sort | Behnaz Hatami |
| collection | DOAJ |
| description | Multisystem inflammatory syndrome in children (MIS-C) is a novel syndrome in children following the coronavirus disease 2019 (COVID-19) pandemic, which has similar symptoms to Kawasaki disease or toxic shock syndrome. The most prevalent symptoms in MIS-C patients are fever and gastrointestinal symptoms, with substantial cardiac complications. Cardiac involvement is frequently reported in MIS-C patients and includes arrhythmia, coronary artery aneurysm and dilation, conduction abnormalities, and ventricular dysfunction. Cardiogenic or vasodilatory shock may develop in patients with severe MIS-C, necessitating inotropic support, fluid resuscitation, mechanical ventilation, and extracorporeal membrane oxygenation. Empirical therapies have attempted to reverse the inflammatory response, and steroids or intravenous immunoglobulin have all been commonly used. Most children will survive with prompt diagnosis and appropriate treatment, but since the disease's outcomes are unclear, long-term follow-ups are necessary. This narrative review summarizes the available studies regarding cardiac involvement in MIS-C cases as well as clinical considerations for cardiac examination and follow-up. |
| first_indexed | 2024-03-11T16:07:50Z |
| format | Article |
| id | doaj.art-f44418637e7d4e2780214ef27b14aff2 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-03-11T16:07:50Z |
| publishDate | 2023-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-f44418637e7d4e2780214ef27b14aff22023-10-24T19:28:19ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922023-03-01101415010.22038/rcm.2023.2244822448Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19Behnaz Hatami0Omid Shoraka1Asef Younesi2Gelayol Bavafa3Melika Zamanian4Niloofar Nikpasand5Amirhossein Mohammadzade6Sara Naghizadeh Kashani7Anoush Azarfar8Mojtaba Yousefi Zoshk9Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Medical Doctor, Research Assistant, Thomas Jefferson University, Philadelphia, USADepartment of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.Multisystem inflammatory syndrome in children (MIS-C) is a novel syndrome in children following the coronavirus disease 2019 (COVID-19) pandemic, which has similar symptoms to Kawasaki disease or toxic shock syndrome. The most prevalent symptoms in MIS-C patients are fever and gastrointestinal symptoms, with substantial cardiac complications. Cardiac involvement is frequently reported in MIS-C patients and includes arrhythmia, coronary artery aneurysm and dilation, conduction abnormalities, and ventricular dysfunction. Cardiogenic or vasodilatory shock may develop in patients with severe MIS-C, necessitating inotropic support, fluid resuscitation, mechanical ventilation, and extracorporeal membrane oxygenation. Empirical therapies have attempted to reverse the inflammatory response, and steroids or intravenous immunoglobulin have all been commonly used. Most children will survive with prompt diagnosis and appropriate treatment, but since the disease's outcomes are unclear, long-term follow-ups are necessary. This narrative review summarizes the available studies regarding cardiac involvement in MIS-C cases as well as clinical considerations for cardiac examination and follow-up.https://rcm.mums.ac.ir/article_22448_0e0e03a6f17532420a3f3443a619a561.pdfmultisystem inflammatory syndrome in childrencovid-19sars-cov-2cardiac involvement |
| spellingShingle | Behnaz Hatami Omid Shoraka Asef Younesi Gelayol Bavafa Melika Zamanian Niloofar Nikpasand Amirhossein Mohammadzade Sara Naghizadeh Kashani Anoush Azarfar Mojtaba Yousefi Zoshk Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19 Reviews in Clinical Medicine multisystem inflammatory syndrome in children covid-19 sars-cov-2 cardiac involvement |
| title | Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19 |
| title_full | Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19 |
| title_fullStr | Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19 |
| title_full_unstemmed | Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19 |
| title_short | Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children Following COVID-19 |
| title_sort | cardiac manifestations of multisystem inflammatory syndrome in children following covid 19 |
| topic | multisystem inflammatory syndrome in children covid-19 sars-cov-2 cardiac involvement |
| url | https://rcm.mums.ac.ir/article_22448_0e0e03a6f17532420a3f3443a619a561.pdf |
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