Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17758-5 |
| _version_ | 1818751731266224128 |
|---|---|
| author | Rafael Núñez-Ramírez Juanjo Huesa Yolanda Bel Juan Ferré Patricia Casino Ernesto Arias-Palomo |
| author_facet | Rafael Núñez-Ramírez Juanjo Huesa Yolanda Bel Juan Ferré Patricia Casino Ernesto Arias-Palomo |
| author_sort | Rafael Núñez-Ramírez |
| collection | DOAJ |
| description | Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation. |
| first_indexed | 2024-12-18T04:40:14Z |
| format | Article |
| id | doaj.art-f4448b8a86204737aec24834ae368c1f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:40:14Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f4448b8a86204737aec24834ae368c1f2022-12-21T21:20:45ZengNature PortfolioNature Communications2041-17232020-08-011111910.1038/s41467-020-17758-5Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensisRafael Núñez-Ramírez0Juanjo Huesa1Yolanda Bel2Juan Ferré3Patricia Casino4Ernesto Arias-Palomo5Centro de Investigaciones Biológicas Margarita Salas, CSICDepartament de Bioquímica i Biologia Molecular, Universitat de ValènciaEstructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de ValènciaEstructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de ValènciaDepartament de Bioquímica i Biologia Molecular, Universitat de ValènciaCentro de Investigaciones Biológicas Margarita Salas, CSICBacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.https://doi.org/10.1038/s41467-020-17758-5 |
| spellingShingle | Rafael Núñez-Ramírez Juanjo Huesa Yolanda Bel Juan Ferré Patricia Casino Ernesto Arias-Palomo Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis Nature Communications |
| title | Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis |
| title_full | Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis |
| title_fullStr | Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis |
| title_full_unstemmed | Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis |
| title_short | Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis |
| title_sort | molecular architecture and activation of the insecticidal protein vip3aa from bacillus thuringiensis |
| url | https://doi.org/10.1038/s41467-020-17758-5 |
| work_keys_str_mv | AT rafaelnunezramirez moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT juanjohuesa moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT yolandabel moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT juanferre moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT patriciacasino moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT ernestoariaspalomo moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis |