Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease
Study objective: Ischemia with non-obstructive coronary arteries (INOCA) is caused by vascular dysfunctions and predominantly seen in women. For better recognition and prevention more insight is needed on risk factors and well-being. We aimed to explore differences in psychological distress, quality...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602223000344 |
| _version_ | 1811154369673953280 |
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| author | Dinah L. van Schalkwijk Jos Widdershoven Michael Magro Veerle Smaardijk Maria Bekendam Ilse Vermeltfoort Paula Mommersteeg |
| author_facet | Dinah L. van Schalkwijk Jos Widdershoven Michael Magro Veerle Smaardijk Maria Bekendam Ilse Vermeltfoort Paula Mommersteeg |
| author_sort | Dinah L. van Schalkwijk |
| collection | DOAJ |
| description | Study objective: Ischemia with non-obstructive coronary arteries (INOCA) is caused by vascular dysfunctions and predominantly seen in women. For better recognition and prevention more insight is needed on risk factors and well-being. We aimed to explore differences in psychological distress, quality of life, risk factors, and medication use between women with INOCA and obstructive coronary artery disease (CAD). Methods: Patients from two separate studies (n = 373, 57 % women) completed a questionnaire assessing psychological and clinical factors. Analyses were performed for women only who were categorized into three groups: non-ischemic chest pain (n = 115), INOCA (n = 68), and obstructive CAD (n = 30). Secondary analyses were performed for men only, and sex differences within INOCA patients were explored. Results and conclusion: Compared to obstructive CAD patients, INOCA patients reported better physical functioning (p = 0.041). Furthermore, INOCA patients had less often hypercholesterolemia (p < 0.001), were less often active smokers (p = 0.062), had a lower mean BMI (p = 0.022), and reported more often a familial history of CAD (p = 0.004). Patients with INOCA used antithrombotic, cholesterol lowering medications, and beta-blockers less often than patients with obstructive CAD. No differences between patients with INOCA and obstructive CAD were found for psychological distress, well-being, and for women-specific risk factors. The results suggest that women with INOCA experience similar levels of psychological distress and seem to have different risk factor profiles and are less optimally treated as compared to obstructive CAD patients. Further research on risk factors is needed for better prevention and treatment. |
| first_indexed | 2024-04-10T04:15:35Z |
| format | Article |
| id | doaj.art-f44530709e224de5a1735711ed6259fc |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-10T04:15:35Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-f44530709e224de5a1735711ed6259fc2023-03-12T04:22:24ZengElsevierAmerican Heart Journal Plus2666-60222023-03-0127100282Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery diseaseDinah L. van Schalkwijk0Jos Widdershoven1Michael Magro2Veerle Smaardijk3Maria Bekendam4Ilse Vermeltfoort5Paula Mommersteeg6Center of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, the Netherlands; Corresponding author at: Department of Medical and Clinical Psychology, Tilburg University, the Netherlands.Center of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, the Netherlands; Department of Cardiology, Elisabeth-TweeSteden Hospital, Tilburg, the NetherlandsDepartment of Cardiology, Elisabeth-TweeSteden Hospital, Tilburg, the NetherlandsCenter of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, the NetherlandsCenter of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, the NetherlandsDepartment of Nuclear Medicine, Institute Verbeeten, Tilburg, the NetherlandsCenter of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, the NetherlandsStudy objective: Ischemia with non-obstructive coronary arteries (INOCA) is caused by vascular dysfunctions and predominantly seen in women. For better recognition and prevention more insight is needed on risk factors and well-being. We aimed to explore differences in psychological distress, quality of life, risk factors, and medication use between women with INOCA and obstructive coronary artery disease (CAD). Methods: Patients from two separate studies (n = 373, 57 % women) completed a questionnaire assessing psychological and clinical factors. Analyses were performed for women only who were categorized into three groups: non-ischemic chest pain (n = 115), INOCA (n = 68), and obstructive CAD (n = 30). Secondary analyses were performed for men only, and sex differences within INOCA patients were explored. Results and conclusion: Compared to obstructive CAD patients, INOCA patients reported better physical functioning (p = 0.041). Furthermore, INOCA patients had less often hypercholesterolemia (p < 0.001), were less often active smokers (p = 0.062), had a lower mean BMI (p = 0.022), and reported more often a familial history of CAD (p = 0.004). Patients with INOCA used antithrombotic, cholesterol lowering medications, and beta-blockers less often than patients with obstructive CAD. No differences between patients with INOCA and obstructive CAD were found for psychological distress, well-being, and for women-specific risk factors. The results suggest that women with INOCA experience similar levels of psychological distress and seem to have different risk factor profiles and are less optimally treated as compared to obstructive CAD patients. Further research on risk factors is needed for better prevention and treatment.http://www.sciencedirect.com/science/article/pii/S2666602223000344Ischemia with non-obstructive coronary arteries (INOCA)Cardiovascular risk factorsPsychological distressWell-beingHealth-related quality of lifeMedication use |
| spellingShingle | Dinah L. van Schalkwijk Jos Widdershoven Michael Magro Veerle Smaardijk Maria Bekendam Ilse Vermeltfoort Paula Mommersteeg Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease American Heart Journal Plus Ischemia with non-obstructive coronary arteries (INOCA) Cardiovascular risk factors Psychological distress Well-being Health-related quality of life Medication use |
| title | Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease |
| title_full | Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease |
| title_fullStr | Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease |
| title_full_unstemmed | Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease |
| title_short | Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease |
| title_sort | clinical and psychological characteristics of patients with ischemia and non obstructive coronary arteries inoca and obstructive coronary artery disease |
| topic | Ischemia with non-obstructive coronary arteries (INOCA) Cardiovascular risk factors Psychological distress Well-being Health-related quality of life Medication use |
| url | http://www.sciencedirect.com/science/article/pii/S2666602223000344 |
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