Optimization Concentration of Irgacure® 2959 as Photo-initiator on Chitosan-Kappa-Carrageenan Based Hydrogel for Tissue Sealant
Hydrogel is a three-dimensional network of hydrophilic polymers widely used in the biomedical field, one of which is a tissue sealant. The material that can be used in the manufacture of hydrogels is chitosan. The ability of chitosan in the formation of hydrogel is still limited by its swelling...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2022-12-01
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| Series: | International Journal of Technology |
| Subjects: | |
| Online Access: | https://ijtech.eng.ui.ac.id/article/view/6166 |
| Summary: | Hydrogel
is a three-dimensional network of hydrophilic polymers widely used in the
biomedical field, one of which is a tissue sealant. The material that can be
used in the manufacture of hydrogels is chitosan. The ability of chitosan in
the formation of hydrogel is still limited by its swelling and adhesive
properties, so it requires other materials such as crosslinkers, one of which
is kappa-carrageenan which can stabilize and increase the viscosity of the
hydrogel. The addition of Irgacure® 2959 as a photo-initiator to the
hydrogel can produce free radicals that can bind to the active group of the
polymer. This study aims to determine the effect of adding Irgacure®
2959 in the manufacture of hydrogel based on a chitosan-kappa-carrageenan
solution formulated as a colon tissue adhesive. The treatments given were the
addition of Irgacure® 2959 as much as 0%, 1%, 2%, 3%, and 4%. The
characteristics of the hydrogel tested qualitatively (simulation adhesion
test), degree of swelling, resistance to water, degree of crystallinity, and
ability to inhibit bacterial growth. The addition of Irgacure® 2959
did not show significantly different results from the control that indicating
it cannot increase the crosslinking between chitosan and kappa-carrageenan.
This is predicted due to the presence of steric hindrance from
kappa-carrageenan, causing very limited crosslinking due to the molecular size
difference between chitosan and kappa-carrageenan. Further, it is necessary to
optimize the ratio of the chitosan and kappa-carrageenan to get the balance
ratio that supports the occurrence of cross-linking. |
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| ISSN: | 2086-9614 2087-2100 |