DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune di...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.931866/full |
| _version_ | 1811310581261533184 |
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| author | Menghui Wang Chuan Xie |
| author_facet | Menghui Wang Chuan Xie |
| author_sort | Menghui Wang |
| collection | DOAJ |
| description | DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune diseases. Therefore, DNA damage repair mechanisms have been proposed as novel antitumor drug targets. To date, numerous drugs targeting DNA damage mechanisms have been developed. For example, PARP inhibitors that elicit synthetic lethality are widely used in individualized cancer therapies. In this review, we describe the latent DNA damage repair mechanisms in gastric cancer, the types of DNA damage that can contribute to the development of gastric cancer, and new therapeutic approaches for gastric cancer that target DNA damage repair pathways. |
| first_indexed | 2024-04-13T10:01:20Z |
| format | Article |
| id | doaj.art-f446a4de26124d0aa1ede55bd95d7d29 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T10:01:20Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-f446a4de26124d0aa1ede55bd95d7d292022-12-22T02:51:14ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.931866931866DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive ReviewMenghui WangChuan XieDNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune diseases. Therefore, DNA damage repair mechanisms have been proposed as novel antitumor drug targets. To date, numerous drugs targeting DNA damage mechanisms have been developed. For example, PARP inhibitors that elicit synthetic lethality are widely used in individualized cancer therapies. In this review, we describe the latent DNA damage repair mechanisms in gastric cancer, the types of DNA damage that can contribute to the development of gastric cancer, and new therapeutic approaches for gastric cancer that target DNA damage repair pathways.https://www.frontiersin.org/articles/10.3389/fgene.2022.931866/fullDNA damage repairHelicobacter pyloritherapeutic approachesgastric cancerPARP inhibitors |
| spellingShingle | Menghui Wang Chuan Xie DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review Frontiers in Genetics DNA damage repair Helicobacter pylori therapeutic approaches gastric cancer PARP inhibitors |
| title | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
| title_full | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
| title_fullStr | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
| title_full_unstemmed | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
| title_short | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
| title_sort | dna damage repair and current therapeutic approaches in gastric cancer a comprehensive review |
| topic | DNA damage repair Helicobacter pylori therapeutic approaches gastric cancer PARP inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.931866/full |
| work_keys_str_mv | AT menghuiwang dnadamagerepairandcurrenttherapeuticapproachesingastriccanceracomprehensivereview AT chuanxie dnadamagerepairandcurrenttherapeuticapproachesingastriccanceracomprehensivereview |