Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor
BACKGROUND: Coronavirus disease 2019 (COVID-19) globally known as COVID-19 is a heterogeneous disease caused by the severe acute respiratory syndrome coronavirus 2. COVID-19 patients having severe disease and are critically ill are more prone to have abnormal coagulation prolife. It may lead to thro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Applied Hematology |
| Subjects: | |
| Online Access: | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2023;volume=14;issue=3;spage=214;epage=224;aulast=Kumarguru |
| _version_ | 1827783216455483392 |
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| author | B N Kumarguru Sindhu Sreegiri D Swathi A S Ramaswamy C A Arathi |
| author_facet | B N Kumarguru Sindhu Sreegiri D Swathi A S Ramaswamy C A Arathi |
| author_sort | B N Kumarguru |
| collection | DOAJ |
| description | BACKGROUND: Coronavirus disease 2019 (COVID-19) globally known as COVID-19 is a heterogeneous disease caused by the severe acute respiratory syndrome coronavirus 2. COVID-19 patients having severe disease and are critically ill are more prone to have abnormal coagulation prolife. It may lead to thromboinflammation in severe conditions.
AIM: The aim is to evaluate the utility of coagulation parameters and inflammatory biomarkers in COVID-19 patients in the study conducted for 6 months duration.
MATERIALS AND METHODS: It was a retrospective observational study conducted from April 2021 to September 2021 in a rural tertiary care referral Institute. Available data of the baseline values of coagulation parameters (platelet count [PLC], prothrombin time [PT], international normalized ratio [INR], partial thromboplastin time [PTT] and D-dimer) and inflammatory markers (C-reactive protein [CRP], serum lactate dehydrogenase [LDH], and serum ferritin) were evaluated with respect to the clinical severity of the disease and also the survival status of COVID-19 patients.
RESULTS: One hundred and fifty-five cases of COVID-19-positive patients were analyzed. PT, INR, PTT, D-dimer, CRP, LDH, and ferritin had higher mean in severe cases than the nonsevere cases. PLC had higher mean in the severe cases than the nonsevere cases. PT, INR, PTT, D-dimer, CRP, LDH and ferritin had higher mean in nonsurvivors than the survivors. PLC had lower mean in nonsurvivors than the survivors.
CONCLUSION: Baseline values of PT, INR, PTT, D-dimer, LDH, and ferritin may be considered reliable indicators of severity of COVID-19 disease. Baseline values of D-dimer, LDH, and ferritin may be considered a reliable indicator of survival of patients suffering from COVID-19 infection. |
| first_indexed | 2024-03-11T15:43:41Z |
| format | Article |
| id | doaj.art-f446c25b58b9496fbcae5f4e227cd842 |
| institution | Directory Open Access Journal |
| issn | 1658-5127 |
| language | English |
| last_indexed | 2024-03-11T15:43:41Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj.art-f446c25b58b9496fbcae5f4e227cd8422023-10-26T08:50:41ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272023-01-0114321422410.4103/joah.joah_41_23Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavorB N KumarguruSindhu SreegiriD SwathiA S RamaswamyC A ArathiBACKGROUND: Coronavirus disease 2019 (COVID-19) globally known as COVID-19 is a heterogeneous disease caused by the severe acute respiratory syndrome coronavirus 2. COVID-19 patients having severe disease and are critically ill are more prone to have abnormal coagulation prolife. It may lead to thromboinflammation in severe conditions. AIM: The aim is to evaluate the utility of coagulation parameters and inflammatory biomarkers in COVID-19 patients in the study conducted for 6 months duration. MATERIALS AND METHODS: It was a retrospective observational study conducted from April 2021 to September 2021 in a rural tertiary care referral Institute. Available data of the baseline values of coagulation parameters (platelet count [PLC], prothrombin time [PT], international normalized ratio [INR], partial thromboplastin time [PTT] and D-dimer) and inflammatory markers (C-reactive protein [CRP], serum lactate dehydrogenase [LDH], and serum ferritin) were evaluated with respect to the clinical severity of the disease and also the survival status of COVID-19 patients. RESULTS: One hundred and fifty-five cases of COVID-19-positive patients were analyzed. PT, INR, PTT, D-dimer, CRP, LDH, and ferritin had higher mean in severe cases than the nonsevere cases. PLC had higher mean in the severe cases than the nonsevere cases. PT, INR, PTT, D-dimer, CRP, LDH and ferritin had higher mean in nonsurvivors than the survivors. PLC had lower mean in nonsurvivors than the survivors. CONCLUSION: Baseline values of PT, INR, PTT, D-dimer, LDH, and ferritin may be considered reliable indicators of severity of COVID-19 disease. Baseline values of D-dimer, LDH, and ferritin may be considered a reliable indicator of survival of patients suffering from COVID-19 infection.http://www.jahjournal.org/article.asp?issn=1658-5127;year=2023;volume=14;issue=3;spage=214;epage=224;aulast=Kumargurucoronavirus disease 2019diseasesevere acute respiratory syndromesurvivors |
| spellingShingle | B N Kumarguru Sindhu Sreegiri D Swathi A S Ramaswamy C A Arathi Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor Journal of Applied Hematology coronavirus disease 2019 disease severe acute respiratory syndrome survivors |
| title | Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor |
| title_full | Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor |
| title_fullStr | Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor |
| title_full_unstemmed | Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor |
| title_short | Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor |
| title_sort | role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients a demystifying endeavor |
| topic | coronavirus disease 2019 disease severe acute respiratory syndrome survivors |
| url | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2023;volume=14;issue=3;spage=214;epage=224;aulast=Kumarguru |
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