The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis.

The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis.

Mycolactones are polyketide-derived lipid virulence factors made by the slow-growing human pathogen, Mycobacterium ulcerans. Three unusually large and homologous plasmid-borne genes (mlsA1: 51 kb, mlsB: 42 kb and mlsA2: 7 kb) encode the mycolactone type I polyketide synthases (PKS). The extreme size...

Full description

Bibliographic Details
Main Authors:	Jessica L Porter, Nicholas J Tobias, Sacha J Pidot, Steffen Falgner, Kellie L Tuck, Andrea Vettiger, Hui Hong, Peter F Leadlay, Timothy P Stinear
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23894666/pdf/?tool=EBI

Similar Items

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones
by: Wilson Peter, et al.
Published: (2008-10-01)

Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.
by: Virginie Roupie, et al.
Published: (2014-01-01)

IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection
by: Aloysius D. Loglo, et al.
Published: (2018-07-01)

Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species.
by: Sacha J Pidot, et al.
Published: (2010-01-01)

The chemistry and biology of mycolactones
by: Matthias Gehringer, et al.
Published: (2017-08-01)

Recombinant Antibodies against Mycolactone
by: Leslie Naranjo, et al.
Published: (2019-06-01)

The potent effect of mycolactone on lipid membranes.
by: Milène Nitenberg, et al.
Published: (2018-01-01)

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters
by: Jérémie Babonneau, et al.
Published: (2019-04-01)

Correction: Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of and Buruli Ulcer.
by: Nicholas J. Tobias, et al.
Published: (2010-02-01)

Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.
by: Nicholas J Tobias, et al.
Published: (2009-01-01)

Regulation of mycolactone, the Mycobacterium ulcerans toxin, depends on nutrient source.
by: Caroline Deshayes, et al.
Published: (2013-11-01)

Mycolactone displays anti-inflammatory effects on the nervous system.
by: Caroline Isaac, et al.
Published: (2017-11-01)

Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.
by: Cesar A López, et al.
Published: (2018-02-01)

Antioxidants protect keratinocytes against M. ulcerans mycolactone cytotoxicity.
by: Alvar Grönberg, et al.
Published: (2010-01-01)

Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.
by: Hui Hong, et al.
Published: (2008-01-01)

From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone
by: Daniela Ricci, et al.
Published: (2023-05-01)

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls
by: Marie-Line Reynaert, et al.
Published: (2019-09-01)

Photodegradation of the Mycobacterium ulcerans toxin, mycolactones: considerations for handling and storage.
by: Estelle Marion, et al.
Published: (2012-01-01)

Understanding the Significance of Biochemistry in the Storage, Handling, Purification, and Sampling of Amphiphilic Mycolactone
by: Jessica Z. Kubicek-Sutherland, et al.
Published: (2019-04-01)

Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue.
by: Fred Stephen Sarfo, et al.
Published: (2010-01-01)

A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone
by: Ok-Ryul Song, et al.
Published: (2017-07-01)

Induced Synthesis of Mycolactone Restores the Pathogenesis of Mycobacterium ulcerans In Vitro and In Vivo
by: Emily Strong, et al.
Published: (2022-03-01)

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.
by: Louisa Warryn, et al.
Published: (2020-06-01)

Environmental Variations in Mycobacterium ulcerans Transcriptome: Absence of Mycolactone Expression in Suboptimal Environments
by: Daniel Sanhueza, et al.
Published: (2019-03-01)

Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
by: Junichiro En, et al.
Published: (2017-08-01)

Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone
by: Bruno Tello Rubio, et al.
Published: (2021-09-01)

Mycolactone induces cell death by SETD1B-dependent degradation of glutathione.
by: Birgit Förster, et al.
Published: (2020-10-01)

Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen.
by: José B Gama, et al.
Published: (2014-08-01)

Density Functional Theory-Based Studies Predict Carbon Nanotubes as Effective Mycolactone Inhibitors
by: Nafiu Suleiman, et al.
Published: (2022-07-01)

Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone
by: Marie Robbe-Saule, et al.
Published: (2021-12-01)

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans.
by: Jean-Pierre Dangy, et al.
Published: (2016-06-01)

Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer
by: Sarah Saint-Auret, et al.
Published: (2017-12-01)

Responses to chemical cross-talk between the Mycobacterium ulcerans toxin, mycolactone, and Staphylococcus aureus
by: Laxmi Dhungel, et al.
Published: (2021-06-01)

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.
by: Emma Colucci-Guyon, et al.
Published: (2020-12-01)

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.
by: Fred S Sarfo, et al.
Published: (2011-07-01)

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases
by: David H. Kwan, et al.
Published: (2011-07-01)

Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.
by: Paul J Converse, et al.
Published: (2014-01-01)

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.
by: Belinda S Hall, et al.
Published: (2014-04-01)

Rate of Production of Inflammatory Cytokines TNF and IL- by Peripheral Blood Mononuclear Cells Stimulated with Mycolactone
by: P Mohajeri, et al.
Published: (2010-08-01)

RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer.
by: Samuel A Sakyi, et al.
Published: (2016-10-01)