Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
Fasciola hepatica is distributed worldwide, causing substantial economic losses in the animal husbandry industry. Human fasciolosis is an emerging zoonosis in Andean America, Asia, and Africa. The control of the disease, both in humans and animals, is based on using anthelmintic drugs, which has res...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1270064/full |
| _version_ | 1797397517729529856 |
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| author | Luis Miguel Flores-Velázquez María Teresa Ruiz-Campillo Guillem Herrera-Torres Álvaro Martínez-Moreno Francisco Javier Martínez-Moreno Rafael Zafra Leandro Buffoni Pablo José Rufino-Moya Verónica Molina-Hernández José Pérez |
| author_facet | Luis Miguel Flores-Velázquez María Teresa Ruiz-Campillo Guillem Herrera-Torres Álvaro Martínez-Moreno Francisco Javier Martínez-Moreno Rafael Zafra Leandro Buffoni Pablo José Rufino-Moya Verónica Molina-Hernández José Pérez |
| author_sort | Luis Miguel Flores-Velázquez |
| collection | DOAJ |
| description | Fasciola hepatica is distributed worldwide, causing substantial economic losses in the animal husbandry industry. Human fasciolosis is an emerging zoonosis in Andean America, Asia, and Africa. The control of the disease, both in humans and animals, is based on using anthelmintic drugs, which has resulted in increased resistance to the most effective anthelmintics, such as triclabendazole, in many countries. This, together with the concerns about drug residues in food and the environment, has increased the interest in preventive measures such as a vaccine to help control the disease in endemic areas. Despite important efforts over the past two decades and the work carried out with numerous vaccine candidates, none of them has demonstrated consistent and reproducible protection in target species. This is at least in part due to the high immunomodulation capacity of the parasite, making ineffective the host response in susceptible species such as ruminants. It is widely accepted that a deeper knowledge of the host-parasite interactions is needed for a more rational design of vaccine candidates. In recent years, the use of emerging technologies has notably increased the amount of data about these interactions. In the present study, current knowledge of host-parasite interactions and their implication in Fasciola hepatica vaccine development is reviewed. |
| first_indexed | 2024-03-09T01:11:10Z |
| format | Article |
| id | doaj.art-f44bad0e8a47425986e8e01a3dddcc74 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-09T01:11:10Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-f44bad0e8a47425986e8e01a3dddcc742023-12-11T06:35:06ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-12-011010.3389/fvets.2023.12700641270064Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine developmentLuis Miguel Flores-Velázquez0María Teresa Ruiz-Campillo1Guillem Herrera-Torres2Álvaro Martínez-Moreno3Francisco Javier Martínez-Moreno4Rafael Zafra5Leandro Buffoni6Pablo José Rufino-Moya7Verónica Molina-Hernández8José Pérez9Unidad de Anatomía, Histología y Patología Veterinaria, Escuela de Medicina Veterinaria, Facultad de Ciencias Naturales, Universidad San Sebastián, Campus Puerto Montt, Puerto Montt, ChileDepartamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Sanidad Animal (Área de Parasitología), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Sanidad Animal (Área de Parasitología), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Sanidad Animal (Área de Parasitología), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Sanidad Animal (Área de Parasitología), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Sanidad Animal (Área de Parasitología), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainDepartamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, SpainFasciola hepatica is distributed worldwide, causing substantial economic losses in the animal husbandry industry. Human fasciolosis is an emerging zoonosis in Andean America, Asia, and Africa. The control of the disease, both in humans and animals, is based on using anthelmintic drugs, which has resulted in increased resistance to the most effective anthelmintics, such as triclabendazole, in many countries. This, together with the concerns about drug residues in food and the environment, has increased the interest in preventive measures such as a vaccine to help control the disease in endemic areas. Despite important efforts over the past two decades and the work carried out with numerous vaccine candidates, none of them has demonstrated consistent and reproducible protection in target species. This is at least in part due to the high immunomodulation capacity of the parasite, making ineffective the host response in susceptible species such as ruminants. It is widely accepted that a deeper knowledge of the host-parasite interactions is needed for a more rational design of vaccine candidates. In recent years, the use of emerging technologies has notably increased the amount of data about these interactions. In the present study, current knowledge of host-parasite interactions and their implication in Fasciola hepatica vaccine development is reviewed.https://www.frontiersin.org/articles/10.3389/fvets.2023.1270064/fullFasciola hepaticapathogenesishost-pathogen interactionimmunomodulationvaccinelivestock |
| spellingShingle | Luis Miguel Flores-Velázquez María Teresa Ruiz-Campillo Guillem Herrera-Torres Álvaro Martínez-Moreno Francisco Javier Martínez-Moreno Rafael Zafra Leandro Buffoni Pablo José Rufino-Moya Verónica Molina-Hernández José Pérez Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development Frontiers in Veterinary Science Fasciola hepatica pathogenesis host-pathogen interaction immunomodulation vaccine livestock |
| title | Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development |
| title_full | Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development |
| title_fullStr | Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development |
| title_full_unstemmed | Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development |
| title_short | Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development |
| title_sort | fasciolosis pathogenesis host parasite interactions and implication in vaccine development |
| topic | Fasciola hepatica pathogenesis host-pathogen interaction immunomodulation vaccine livestock |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1270064/full |
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