Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
Hongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-05-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/influence-of-covid-19-on-cerebrovascular-disease-and-its-possible-mech-peer-reviewed-article-NDT |
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| author | Fan H Tang X Song Y Liu P Chen Y |
| author_facet | Fan H Tang X Song Y Liu P Chen Y |
| author_sort | Fan H |
| collection | DOAJ |
| description | Hongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province, People’s Republic of China; 3Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingzhu Chen; Peipei Liu Email yzchendr@163.com; doclpp87@163.comAbstract: The global spread of COVID-19 has caused a substantial societal burden and become a major global public health issue. The COVID-19 elderly population with hypertension, diabetes, cardiovascular, and cerebrovascular diseases are at risk. Mortality rates are highest in these individuals if infected with COVID-19. Although the lungs are the main organs involved in acute respiratory distress syndrome caused by COVID-19 infection, COVID-19 triggers inflammatory and immune mechanisms, inducing a “cytokine storm” that aggravates disease progression and may lead to death. Presently, effective drugs are lacking, although current studies have confirmed that drugs with therapeutic potential include redaciclovir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. Currently, the most reasonable and effective way to prevent COVID-19 is to control the source of infection, terminate routes of transmission, and protect susceptible populations. With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. Cerebrovascular disease has high incidence, disability rate, and fatality rate. COVID-19 patient outcomes may also be complicated with acute stroke. This paper summarizes the influence of COVID-19 on cerebrovascular disease and discusses possible pathophysiological mechanisms to provide new angles for the prevention and diagnosis of this disease.Keywords: novel coronavirus pneumonia, 2019-nCoV, SARS-CoV-2, cerebral vascular disease |
| first_indexed | 2024-12-14T13:18:12Z |
| format | Article |
| id | doaj.art-f44c0c57091c4eea8e0c258d3d824bae |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-14T13:18:12Z |
| publishDate | 2020-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-f44c0c57091c4eea8e0c258d3d824bae2022-12-21T23:00:00ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212020-05-01Volume 161359136754159Influence of COVID-19 on Cerebrovascular Disease and its Possible MechanismFan HTang XSong YLiu PChen YHongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province, People’s Republic of China; 3Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingzhu Chen; Peipei Liu Email yzchendr@163.com; doclpp87@163.comAbstract: The global spread of COVID-19 has caused a substantial societal burden and become a major global public health issue. The COVID-19 elderly population with hypertension, diabetes, cardiovascular, and cerebrovascular diseases are at risk. Mortality rates are highest in these individuals if infected with COVID-19. Although the lungs are the main organs involved in acute respiratory distress syndrome caused by COVID-19 infection, COVID-19 triggers inflammatory and immune mechanisms, inducing a “cytokine storm” that aggravates disease progression and may lead to death. Presently, effective drugs are lacking, although current studies have confirmed that drugs with therapeutic potential include redaciclovir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. Currently, the most reasonable and effective way to prevent COVID-19 is to control the source of infection, terminate routes of transmission, and protect susceptible populations. With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. Cerebrovascular disease has high incidence, disability rate, and fatality rate. COVID-19 patient outcomes may also be complicated with acute stroke. This paper summarizes the influence of COVID-19 on cerebrovascular disease and discusses possible pathophysiological mechanisms to provide new angles for the prevention and diagnosis of this disease.Keywords: novel coronavirus pneumonia, 2019-nCoV, SARS-CoV-2, cerebral vascular diseasehttps://www.dovepress.com/influence-of-covid-19-on-cerebrovascular-disease-and-its-possible-mech-peer-reviewed-article-NDTnovel coronavirus pneumonia2019-ncovsars-cov-2cerebral vascular disease |
| spellingShingle | Fan H Tang X Song Y Liu P Chen Y Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism Neuropsychiatric Disease and Treatment novel coronavirus pneumonia 2019-ncov sars-cov-2 cerebral vascular disease |
| title | Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism |
| title_full | Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism |
| title_fullStr | Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism |
| title_full_unstemmed | Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism |
| title_short | Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism |
| title_sort | influence of covid 19 on cerebrovascular disease and its possible mechanism |
| topic | novel coronavirus pneumonia 2019-ncov sars-cov-2 cerebral vascular disease |
| url | https://www.dovepress.com/influence-of-covid-19-on-cerebrovascular-disease-and-its-possible-mech-peer-reviewed-article-NDT |
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