TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling part...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/15/2336 |
| _version_ | 1797442540536856576 |
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| author | Soumaya Hachana Bruno Larrivée |
| author_facet | Soumaya Hachana Bruno Larrivée |
| author_sort | Soumaya Hachana |
| collection | DOAJ |
| description | The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling participates in regulating several key developmental processes in the eye, including angiogenesis and neurogenesis. Inadequate TGF-β signaling has been associated with defective angiogenesis, vascular barrier function, unfavorable inflammatory responses, and tissue fibrosis. In addition, experimental models of corneal neovascularization, diabetic retinopathy, proliferative vitreoretinopathy, glaucoma, or corneal injury suggest that aberrant TGF-β signaling may contribute to the pathological features of these conditions, showing the potential of modulating TGF-β signaling to treat eye diseases. This review highlights the key roles of TGF-β family members in ocular physiology and in eye diseases, and reviews approaches targeting the TGF-β signaling as potential treatment options. |
| first_indexed | 2024-03-09T12:43:21Z |
| format | Article |
| id | doaj.art-f44ccf4c9cdf4e01af49e4c24d4c3b54 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:43:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f44ccf4c9cdf4e01af49e4c24d4c3b542023-11-30T22:15:55ZengMDPI AGCells2073-44092022-07-011115233610.3390/cells11152336TGF-β Superfamily Signaling in the Eye: Implications for Ocular PathologiesSoumaya Hachana0Bruno Larrivée1Maisonneuve-Rosemont Hospital Research Center, Montreal, QC H1T 2M4, CanadaMaisonneuve-Rosemont Hospital Research Center, Montreal, QC H1T 2M4, CanadaThe TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling participates in regulating several key developmental processes in the eye, including angiogenesis and neurogenesis. Inadequate TGF-β signaling has been associated with defective angiogenesis, vascular barrier function, unfavorable inflammatory responses, and tissue fibrosis. In addition, experimental models of corneal neovascularization, diabetic retinopathy, proliferative vitreoretinopathy, glaucoma, or corneal injury suggest that aberrant TGF-β signaling may contribute to the pathological features of these conditions, showing the potential of modulating TGF-β signaling to treat eye diseases. This review highlights the key roles of TGF-β family members in ocular physiology and in eye diseases, and reviews approaches targeting the TGF-β signaling as potential treatment options.https://www.mdpi.com/2073-4409/11/15/2336TGF-βBMPocular diseasesage-related macular degeneration |
| spellingShingle | Soumaya Hachana Bruno Larrivée TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies Cells TGF-β BMP ocular diseases age-related macular degeneration |
| title | TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies |
| title_full | TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies |
| title_fullStr | TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies |
| title_full_unstemmed | TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies |
| title_short | TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies |
| title_sort | tgf β superfamily signaling in the eye implications for ocular pathologies |
| topic | TGF-β BMP ocular diseases age-related macular degeneration |
| url | https://www.mdpi.com/2073-4409/11/15/2336 |
| work_keys_str_mv | AT soumayahachana tgfbsuperfamilysignalingintheeyeimplicationsforocularpathologies AT brunolarrivee tgfbsuperfamilysignalingintheeyeimplicationsforocularpathologies |