Targeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats

Abstract Background The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erbα in ischemia-reperfusion (IR)-induced acute lung injury (ALI) remains unclear. Methods Th...

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Bibliographic Details
Main Authors: Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu, Shih-En Tang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-023-02547-7