How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?

How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?

Tumour suppressor p53 plays a key role in the development of cancer and has therefore been widely studied in recent decades. While it is well known that p53 is biologically active as a tetramer, the tetramerisation mechanism is still not completely understood. p53 is mutated in nearly 50% of cancers...

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Bibliographic Details
Main Authors: Federica Nicolini, Toni Todorovski, Eduard Puig, Mireia Díaz-Lobo, Marta Vilaseca, Jesús García, David Andreu, Ernest Giralt
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Current Issues in Molecular Biology
Subjects:
p53
p53 tetramerisation domain
cancer mutations
native MS
high-field NMR
diffusion NMR
Online Access:https://www.mdpi.com/1467-3045/45/6/317

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