Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations
The incompatibility of membrane materials with blood in the dialysis process has resulted in extensive number of side effects as well as undesired mortality rates for end-stage renal disease (ESRD) patients. Recent attention has been directed at enhancing the hemocompatibility of dialysis membranes....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Results in Surfaces and Interfaces |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666845923000661 |
| _version_ | 1797399045585502208 |
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| author | Anubhab Patra Jumanah Bahig Denis Kalugin Arash Mollahosseini Ahmed Shoker Amira Abdelrasoul |
| author_facet | Anubhab Patra Jumanah Bahig Denis Kalugin Arash Mollahosseini Ahmed Shoker Amira Abdelrasoul |
| author_sort | Anubhab Patra |
| collection | DOAJ |
| description | The incompatibility of membrane materials with blood in the dialysis process has resulted in extensive number of side effects as well as undesired mortality rates for end-stage renal disease (ESRD) patients. Recent attention has been directed at enhancing the hemocompatibility of dialysis membranes. This study synthesized polyether sulfone (PES) mixed matrix membranes (MMMs) containing modified silica nanoparticles (SiO2 NPs) using the phase inversion technique. SiO2 NPs were modified with pseudo-zwitterionic (pZW) coatings of different structures. The modification of SiO2 NPs and their presence in casted MMMs were confirmed using Fourier-transform infrared (FTIR) spectroscopy. Molecular dynamics (MD) simulations were used to compute the quantity and energy of hydrogen bonds, which serve as a metric of hemocompatibility. Surface charge measurements were used to confirm the neutralization of the modified membrane surface charge. Atomic force microscopy (AFM) analysis revealed the influence of the structure of the SiO2 NPs on casted MMM surface roughness. The influence of the pZW coating structure on MMM hemocompatibility was examined in vitro using patient serum to investigate the inflammatory biomarkers released (C5a, IL-1α, IL-1β, IL-6, properdin, C5b-9). The clinicalex-vivo studies showed improvement of hemocompatibility in terms of IL-1α, IL-1β, Properdin, and C59-9. 5 % lower secretion of complement factor and interleukins reflected an improvement of hemocompatibility. Comparing MMM-1 to the other samples, the hemocompatibility profile was better. MD results were in agreement with the clinical outcomes as MMM-1 had the highest number of hydrogen bonds (8) and hydrogen bonding energy value (0.72 kcal/mol), indicating greater water interaction. |
| first_indexed | 2024-03-09T01:33:45Z |
| format | Article |
| id | doaj.art-f44f16dca9944aac80f40eade82f1194 |
| institution | Directory Open Access Journal |
| issn | 2666-8459 |
| language | English |
| last_indexed | 2024-03-09T01:33:45Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Surfaces and Interfaces |
| spelling | doaj.art-f44f16dca9944aac80f40eade82f11942023-12-09T06:08:23ZengElsevierResults in Surfaces and Interfaces2666-84592023-10-0113100159Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientationsAnubhab Patra0Jumanah Bahig1Denis Kalugin2Arash Mollahosseini3Ahmed Shoker4Amira Abdelrasoul5Department of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, CanadaDivision of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada; Division of Nephrology, College of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK, S7N 5E5, CanadaDepartment of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, CanadaDepartment of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, CanadaDivision of Nephrology, College of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK, S7N 5E5, Canada; Saskatchewan Transplant Program, St. Paul's Hospital, 1702 20th Street West, Saskatoon, SK, S7M 0Z9, CanadaDepartment of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada; Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada; Corresponding author. Department of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada.The incompatibility of membrane materials with blood in the dialysis process has resulted in extensive number of side effects as well as undesired mortality rates for end-stage renal disease (ESRD) patients. Recent attention has been directed at enhancing the hemocompatibility of dialysis membranes. This study synthesized polyether sulfone (PES) mixed matrix membranes (MMMs) containing modified silica nanoparticles (SiO2 NPs) using the phase inversion technique. SiO2 NPs were modified with pseudo-zwitterionic (pZW) coatings of different structures. The modification of SiO2 NPs and their presence in casted MMMs were confirmed using Fourier-transform infrared (FTIR) spectroscopy. Molecular dynamics (MD) simulations were used to compute the quantity and energy of hydrogen bonds, which serve as a metric of hemocompatibility. Surface charge measurements were used to confirm the neutralization of the modified membrane surface charge. Atomic force microscopy (AFM) analysis revealed the influence of the structure of the SiO2 NPs on casted MMM surface roughness. The influence of the pZW coating structure on MMM hemocompatibility was examined in vitro using patient serum to investigate the inflammatory biomarkers released (C5a, IL-1α, IL-1β, IL-6, properdin, C5b-9). The clinicalex-vivo studies showed improvement of hemocompatibility in terms of IL-1α, IL-1β, Properdin, and C59-9. 5 % lower secretion of complement factor and interleukins reflected an improvement of hemocompatibility. Comparing MMM-1 to the other samples, the hemocompatibility profile was better. MD results were in agreement with the clinical outcomes as MMM-1 had the highest number of hydrogen bonds (8) and hydrogen bonding energy value (0.72 kcal/mol), indicating greater water interaction.http://www.sciencedirect.com/science/article/pii/S2666845923000661HemodialysisMixed matrix membranePoly ether sulfonePseudo zwitterionicHemocompatibilityClinical |
| spellingShingle | Anubhab Patra Jumanah Bahig Denis Kalugin Arash Mollahosseini Ahmed Shoker Amira Abdelrasoul Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations Results in Surfaces and Interfaces Hemodialysis Mixed matrix membrane Poly ether sulfone Pseudo zwitterionic Hemocompatibility Clinical |
| title | Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations |
| title_full | Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations |
| title_fullStr | Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations |
| title_full_unstemmed | Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations |
| title_short | Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations |
| title_sort | enhancing the hemocompatibility of polyethersulfone pes hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations |
| topic | Hemodialysis Mixed matrix membrane Poly ether sulfone Pseudo zwitterionic Hemocompatibility Clinical |
| url | http://www.sciencedirect.com/science/article/pii/S2666845923000661 |
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