Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase
Lansky et al. describe the structural analysis of an ultra-multimodular GH43 arabinanase, AbnA. They discover a new carbohydrate binding module and analyze the large conformational transitions of the enzyme with the integrative structure determination approach, which may be applied to the conformati...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03054-z |
| _version_ | 1818548694481371136 |
|---|---|
| author | Shifra Lansky Rachel Salama Xevi Biarnés Omer Shwartstein Dina Schneidman-Duhovny Antoni Planas Yuval Shoham Gil Shoham |
| author_facet | Shifra Lansky Rachel Salama Xevi Biarnés Omer Shwartstein Dina Schneidman-Duhovny Antoni Planas Yuval Shoham Gil Shoham |
| author_sort | Shifra Lansky |
| collection | DOAJ |
| description | Lansky et al. describe the structural analysis of an ultra-multimodular GH43 arabinanase, AbnA. They discover a new carbohydrate binding module and analyze the large conformational transitions of the enzyme with the integrative structure determination approach, which may be applied to the conformational studies of other ultramultimodular proteins as well. |
| first_indexed | 2024-12-12T08:23:36Z |
| format | Article |
| id | doaj.art-f44f59de63d243479023e2433fb7a80e |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-12T08:23:36Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f44f59de63d243479023e2433fb7a80e2022-12-22T00:31:20ZengNature PortfolioCommunications Biology2399-36422022-05-015111410.1038/s42003-022-03054-zIntegrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanaseShifra Lansky0Rachel Salama1Xevi Biarnés2Omer Shwartstein3Dina Schneidman-Duhovny4Antoni Planas5Yuval Shoham6Gil Shoham7Institute of Chemistry, the Hebrew University of JerusalemDepartment of Biotechnology and Food Engineering, TechnionLaboratory of Biochemistry, Institut Químic de Sarrià, Universitat Ramon LlullInstitute of Chemistry, the Hebrew University of JerusalemSchool of Computer Science and Engineering, the Hebrew University of JerusalemLaboratory of Biochemistry, Institut Químic de Sarrià, Universitat Ramon LlullDepartment of Biotechnology and Food Engineering, TechnionInstitute of Chemistry, the Hebrew University of JerusalemLansky et al. describe the structural analysis of an ultra-multimodular GH43 arabinanase, AbnA. They discover a new carbohydrate binding module and analyze the large conformational transitions of the enzyme with the integrative structure determination approach, which may be applied to the conformational studies of other ultramultimodular proteins as well.https://doi.org/10.1038/s42003-022-03054-z |
| spellingShingle | Shifra Lansky Rachel Salama Xevi Biarnés Omer Shwartstein Dina Schneidman-Duhovny Antoni Planas Yuval Shoham Gil Shoham Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase Communications Biology |
| title | Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase |
| title_full | Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase |
| title_fullStr | Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase |
| title_full_unstemmed | Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase |
| title_short | Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase |
| title_sort | integrative structure determination reveals functional global flexibility for an ultra multimodular arabinanase |
| url | https://doi.org/10.1038/s42003-022-03054-z |
| work_keys_str_mv | AT shifralansky integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT rachelsalama integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT xevibiarnes integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT omershwartstein integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT dinaschneidmanduhovny integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT antoniplanas integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT yuvalshoham integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase AT gilshoham integrativestructuredeterminationrevealsfunctionalglobalflexibilityforanultramultimodulararabinanase |