Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer
ABSTRACTCheckpoint blockade immunotherapy transforms many types of cancer; however, in the field of metastatic colorectal cancer, checkpoint blockers are only effective in microsatellite-unstable tumors, which represent only a minority of patients. Microsatellite-stable tumors are thought to be immu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2257098 |
| _version_ | 1797367163047116800 |
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| author | Marion Thibaudin Francois Ghiringhelli |
| author_facet | Marion Thibaudin Francois Ghiringhelli |
| author_sort | Marion Thibaudin |
| collection | DOAJ |
| description | ABSTRACTCheckpoint blockade immunotherapy transforms many types of cancer; however, in the field of metastatic colorectal cancer, checkpoint blockers are only effective in microsatellite-unstable tumors, which represent only a minority of patients. Microsatellite-stable tumors are thought to be immunoresistant. A recent publication demonstrates that, contrary to the standard view point, the combination of chemo-immunotherapy could trigger a tumor-specific immune response, leading to clinical benefit. |
| first_indexed | 2024-03-08T17:13:25Z |
| format | Article |
| id | doaj.art-f451b3f0b7a7407097944215a0f8019d |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-03-08T17:13:25Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-f451b3f0b7a7407097944215a0f8019d2024-01-03T19:25:37ZengTaylor & Francis GroupOncoImmunology2162-402X2023-12-0112110.1080/2162402X.2023.2257098Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancerMarion Thibaudin0Francois Ghiringhelli1University of Bourgogne, Dijon, FranceUniversity of Bourgogne, Dijon, FranceABSTRACTCheckpoint blockade immunotherapy transforms many types of cancer; however, in the field of metastatic colorectal cancer, checkpoint blockers are only effective in microsatellite-unstable tumors, which represent only a minority of patients. Microsatellite-stable tumors are thought to be immunoresistant. A recent publication demonstrates that, contrary to the standard view point, the combination of chemo-immunotherapy could trigger a tumor-specific immune response, leading to clinical benefit.https://www.tandfonline.com/doi/10.1080/2162402X.2023.2257098Checkpoint blockadeclinical trialcolorectal cancerimmunogenic cell death |
| spellingShingle | Marion Thibaudin Francois Ghiringhelli Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer OncoImmunology Checkpoint blockade clinical trial colorectal cancer immunogenic cell death |
| title | Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer |
| title_full | Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer |
| title_fullStr | Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer |
| title_full_unstemmed | Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer |
| title_short | Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer |
| title_sort | chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer |
| topic | Checkpoint blockade clinical trial colorectal cancer immunogenic cell death |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2257098 |
| work_keys_str_mv | AT marionthibaudin chemoimmunotherapytriggersimmuneresponsestargetingmicrosatellitestablecolorectalcancer AT francoisghiringhelli chemoimmunotherapytriggersimmuneresponsestargetingmicrosatellitestablecolorectalcancer |