Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats
Purpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10)....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5144 |
| _version_ | 1818210781597007872 |
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| author | R. Tachibana H. Matsushita A. Minami N. Morita S. Shimizu H. Kanazawa T. Suzuki K. Watanabe A. Wakatsuki |
| author_facet | R. Tachibana H. Matsushita A. Minami N. Morita S. Shimizu H. Kanazawa T. Suzuki K. Watanabe A. Wakatsuki |
| author_sort | R. Tachibana |
| collection | DOAJ |
| description | Purpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10). Animals in the BC group were sacrificed immediately. Rats in the other groups underwent sham surgery (Sham) or bilateral ovariectomy (Ovx and Ovx + SSI). Rats in the Ovx + SSI group were given custom diets, and BMD and bone histomorphometry were evaluated 13 weeks post-surgery. Results: The femur BMD in the Ovx + SSI group was lower than in the Ovx group, as were the measurements for bone formation rate and mineralizing surface. Conclusion: Administration of a methanol extract of sesame seeds decreased femur BMD in Ovx rats. |
| first_indexed | 2024-12-12T05:22:04Z |
| format | Article |
| id | doaj.art-f4535fa5f2b14ec98ebf076ff7888daf |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T05:22:04Z |
| publishDate | 2020-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-f4535fa5f2b14ec98ebf076ff7888daf2022-12-22T00:36:36ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-08-0147454655110.31083/j.ceog.2020.04.5144S0390-6663(20)00308-5Dietary sesame diminishes bone mass and bone formation indices in ovariectomized ratsR. Tachibana0H. Matsushita1A. Minami2N. Morita3S. Shimizu4H. Kanazawa5T. Suzuki6K. Watanabe7A. Wakatsuki8Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, JapanDepartment of Functional Anatomy, School of Nursing, University of Shizuoka, Shizuoka, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute, Aichi, JapanPurpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10). Animals in the BC group were sacrificed immediately. Rats in the other groups underwent sham surgery (Sham) or bilateral ovariectomy (Ovx and Ovx + SSI). Rats in the Ovx + SSI group were given custom diets, and BMD and bone histomorphometry were evaluated 13 weeks post-surgery. Results: The femur BMD in the Ovx + SSI group was lower than in the Ovx group, as were the measurements for bone formation rate and mineralizing surface. Conclusion: Administration of a methanol extract of sesame seeds decreased femur BMD in Ovx rats.https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5144bone mineral densitybone histomorphometrymenopauseovariectomyratsesame |
| spellingShingle | R. Tachibana H. Matsushita A. Minami N. Morita S. Shimizu H. Kanazawa T. Suzuki K. Watanabe A. Wakatsuki Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats Clinical and Experimental Obstetrics & Gynecology bone mineral density bone histomorphometry menopause ovariectomy rat sesame |
| title | Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats |
| title_full | Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats |
| title_fullStr | Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats |
| title_full_unstemmed | Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats |
| title_short | Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats |
| title_sort | dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats |
| topic | bone mineral density bone histomorphometry menopause ovariectomy rat sesame |
| url | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5144 |
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