A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
The relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1409864 |
| _version_ | 1827809497490391040 |
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| author | Hyeongsun Moon Andrew C. White |
| author_facet | Hyeongsun Moon Andrew C. White |
| author_sort | Hyeongsun Moon |
| collection | DOAJ |
| description | The relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescence is sufficient to suppress tumorigenesis. This provides new insight into the role of environmental factors in tumor initiation from adult stem cells. |
| first_indexed | 2024-03-11T22:41:21Z |
| format | Article |
| id | doaj.art-f4536e68cac447fdbf46198ccefd3c86 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:21Z |
| publishDate | 2018-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-f4536e68cac447fdbf46198ccefd3c862023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-03-015210.1080/23723556.2017.14098641409864A path from melanocyte stem cells to cutaneous melanoma illuminated by UVBHyeongsun Moon0Andrew C. White1Cornell UniversityCornell UniversityThe relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescence is sufficient to suppress tumorigenesis. This provides new insight into the role of environmental factors in tumor initiation from adult stem cells.http://dx.doi.org/10.1080/23723556.2017.1409864melanoma originmelanocyte stem cellsskinuvb |
| spellingShingle | Hyeongsun Moon Andrew C. White A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB Molecular & Cellular Oncology melanoma origin melanocyte stem cells skin uvb |
| title | A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB |
| title_full | A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB |
| title_fullStr | A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB |
| title_full_unstemmed | A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB |
| title_short | A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB |
| title_sort | path from melanocyte stem cells to cutaneous melanoma illuminated by uvb |
| topic | melanoma origin melanocyte stem cells skin uvb |
| url | http://dx.doi.org/10.1080/23723556.2017.1409864 |
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