Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy
This study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2022-01-01
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| Series: | IEEE Access |
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| Online Access: | https://ieeexplore.ieee.org/document/9903444/ |
| _version_ | 1798028104301543424 |
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| author | Georgina Company-Se Lexa Nescolarde Virginia Pajares Alfons Torrego Pere J. Riu Javier Rosell Ramon Bragos |
| author_facet | Georgina Company-Se Lexa Nescolarde Virginia Pajares Alfons Torrego Pere J. Riu Javier Rosell Ramon Bragos |
| author_sort | Georgina Company-Se |
| collection | DOAJ |
| description | This study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99 patients [54 healthy tissue and 15 neoplastic tissue samples obtained] with an indicated bronchoscopy. Statistically significant difference (P < 0.001) were found between healthy lung tissue and neoplasm lung tissue in bioimpedance parameters. The calibration of the bioimpedance measures with respect to a measure performed in bronchi reduces the inter-patient dispersion, increasing the sensitivity, decreasing the specificity and increasing the area below the ROC curve for three out of four impedance-derived estimators. Results also show that there are no significant differences between healthy lung tissue among smoker, non-smoker and ex-smoker samples, which was initially stated as a possible cause of EIS measurement dispersion in lungs. |
| first_indexed | 2024-04-11T19:03:36Z |
| format | Article |
| id | doaj.art-f4547a62b31c46969423f74874451a4c |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-04-11T19:03:36Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-f4547a62b31c46969423f74874451a4c2022-12-22T04:07:56ZengIEEEIEEE Access2169-35362022-01-011010315010316310.1109/ACCESS.2022.32098099903444Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance SpectroscopyGeorgina Company-Se0https://orcid.org/0000-0002-0473-4955Lexa Nescolarde1https://orcid.org/0000-0001-6861-5106Virginia Pajares2Alfons Torrego3Pere J. Riu4https://orcid.org/0000-0003-0477-1972Javier Rosell5https://orcid.org/0000-0002-9691-328XRamon Bragos6https://orcid.org/0000-0002-1373-1588Department of Electronic Engineering, Universitat Politécnica de Catalunya, Barcelona, SpainDepartment of Electronic Engineering, Universitat Politécnica de Catalunya, Barcelona, SpainDepartment of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainDepartment of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainDepartment of Electronic Engineering, Universitat Politécnica de Catalunya, Barcelona, SpainDepartment of Electronic Engineering, Universitat Politécnica de Catalunya, Barcelona, SpainDepartment of Electronic Engineering, Universitat Politécnica de Catalunya, Barcelona, SpainThis study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99 patients [54 healthy tissue and 15 neoplastic tissue samples obtained] with an indicated bronchoscopy. Statistically significant difference (P < 0.001) were found between healthy lung tissue and neoplasm lung tissue in bioimpedance parameters. The calibration of the bioimpedance measures with respect to a measure performed in bronchi reduces the inter-patient dispersion, increasing the sensitivity, decreasing the specificity and increasing the area below the ROC curve for three out of four impedance-derived estimators. Results also show that there are no significant differences between healthy lung tissue among smoker, non-smoker and ex-smoker samples, which was initially stated as a possible cause of EIS measurement dispersion in lungs.https://ieeexplore.ieee.org/document/9903444/Bronchibronchoscopycalibrationelectrical impedance spectroscopy (EIS)lung |
| spellingShingle | Georgina Company-Se Lexa Nescolarde Virginia Pajares Alfons Torrego Pere J. Riu Javier Rosell Ramon Bragos Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy IEEE Access Bronchi bronchoscopy calibration electrical impedance spectroscopy (EIS) lung |
| title | Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy |
| title_full | Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy |
| title_fullStr | Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy |
| title_full_unstemmed | Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy |
| title_short | Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy |
| title_sort | effect of calibration for tissue differentiation between healthy and neoplasm lung using minimally invasive electrical impedance spectroscopy |
| topic | Bronchi bronchoscopy calibration electrical impedance spectroscopy (EIS) lung |
| url | https://ieeexplore.ieee.org/document/9903444/ |
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