High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis
In the review show the functions of high-density lipoprotein, is not related to the exchange of lipids within them. The results own research, as well as literary evidenced of the important regula tory role. Regulatory effect of HDL is closely related to their antiatherogenic properties. However, it...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2013-03-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/665/603 |
| _version_ | 1828073686578495488 |
|---|---|
| author | L. M. Polyakov L. E. Panin |
| author_facet | L. M. Polyakov L. E. Panin |
| author_sort | L. M. Polyakov |
| collection | DOAJ |
| description | In the review show the functions of high-density lipoprotein, is not related to the exchange of lipids within them. The results own research, as well as literary evidenced of the important regula tory role. Regulatory effect of HDL is closely related to their antiatherogenic properties. However, it should be noted that the mechanism of action of antiatherogenic HDL is not limited to a “reverse” transport of cholesterol from peripheral tissues to the liver, it is determined by many other factors, all of which is important not only in the context of defense against athe ro sclerosis, but also in the protective role of HDL in a broader sense. The data show that HDL has an important antiinflammatory effect, have antioxidant and antiapoptotic properties, regulate vascular tone and anticoagulant activity, act as antimicrobial and antiviral agents. Due to the urgency of the problem of atherosclerosis in the emphasis that understanding the molecular mechanisms of the regulatory properties of HDL opens up new prospects for the development of more effective treatments for this disease. New treatment strategies should include the development of promising therapeutic approaches that modulate HDL metabolism, which would increase their levels in the blood and improve the “reverse” cholesterol transport. This review deals with, in our opinion, the two most promising areas – is the creation and use of recombinant HDL or reconstructed, as well as peptide-mimetics of apolipoprotein A-I. |
| first_indexed | 2024-04-11T01:33:09Z |
| format | Article |
| id | doaj.art-f455c1618c844bb5816f0789c3998a59 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:33:09Z |
| publishDate | 2013-03-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-f455c1618c844bb5816f0789c3998a592023-01-03T09:23:34ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2013-03-01914253High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosisL. M. Polyakov0L. E. Panin1RAMS Russian Federation SB RAMS Federal state budgetary institution "Research Institute of Biochemistry"RAMS Russian Federation SB RAMS Federal state budgetary institution "Research Institute of Biochemistry" In the review show the functions of high-density lipoprotein, is not related to the exchange of lipids within them. The results own research, as well as literary evidenced of the important regula tory role. Regulatory effect of HDL is closely related to their antiatherogenic properties. However, it should be noted that the mechanism of action of antiatherogenic HDL is not limited to a “reverse” transport of cholesterol from peripheral tissues to the liver, it is determined by many other factors, all of which is important not only in the context of defense against athe ro sclerosis, but also in the protective role of HDL in a broader sense. The data show that HDL has an important antiinflammatory effect, have antioxidant and antiapoptotic properties, regulate vascular tone and anticoagulant activity, act as antimicrobial and antiviral agents. Due to the urgency of the problem of atherosclerosis in the emphasis that understanding the molecular mechanisms of the regulatory properties of HDL opens up new prospects for the development of more effective treatments for this disease. New treatment strategies should include the development of promising therapeutic approaches that modulate HDL metabolism, which would increase their levels in the blood and improve the “reverse” cholesterol transport. This review deals with, in our opinion, the two most promising areas – is the creation and use of recombinant HDL or reconstructed, as well as peptide-mimetics of apolipoprotein A-I.https://ateroskleroz.elpub.ru/jour/article/view/665/603atherosclerosishigh-density lipoproteinapolipoprotein a-ithe regulatory role of apoa-i-mimetic peptidestreatment strategies |
| spellingShingle | L. M. Polyakov L. E. Panin High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis Атеросклероз atherosclerosis high-density lipoprotein apolipoprotein a-i the regulatory role of apoa-i-mimetic peptides treatment strategies |
| title | High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis |
| title_full | High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis |
| title_fullStr | High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis |
| title_full_unstemmed | High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis |
| title_short | High-density lipoprotein, and apolipoprotein A-I: a regulatory role and novel therapeutic strategies for the treatment atherosclerosis |
| title_sort | high density lipoprotein and apolipoprotein a i a regulatory role and novel therapeutic strategies for the treatment atherosclerosis |
| topic | atherosclerosis high-density lipoprotein apolipoprotein a-i the regulatory role of apoa-i-mimetic peptides treatment strategies |
| url | https://ateroskleroz.elpub.ru/jour/article/view/665/603 |
| work_keys_str_mv | AT lmpolyakov highdensitylipoproteinandapolipoproteinaiaregulatoryroleandnoveltherapeuticstrategiesforthetreatmentatherosclerosis AT lepanin highdensitylipoproteinandapolipoproteinaiaregulatoryroleandnoveltherapeuticstrategiesforthetreatmentatherosclerosis |