Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice
Growing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain i...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00995/full |
| _version_ | 1818317758147854336 |
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| author | Jae-Hwan Jang Jae-Hwan Jang Jae-Hwan Jang Yu-Kang Kim Yu-Kang Kim Won-Mo Jung Hyung-Kyu Kim Eun-Mo Song Hee-Young Kim Ju-Young Oh Ju-Young Oh Ju-Young Oh Ji-Yeun Park Yeonhee Ryu Mi-Yeon Song Hi-Joon Park Hi-Joon Park Hi-Joon Park |
| author_facet | Jae-Hwan Jang Jae-Hwan Jang Jae-Hwan Jang Yu-Kang Kim Yu-Kang Kim Won-Mo Jung Hyung-Kyu Kim Eun-Mo Song Hee-Young Kim Ju-Young Oh Ju-Young Oh Ju-Young Oh Ji-Yeun Park Yeonhee Ryu Mi-Yeon Song Hi-Joon Park Hi-Joon Park Hi-Joon Park |
| author_sort | Jae-Hwan Jang |
| collection | DOAJ |
| description | Growing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain in mice. One week after the left partial sciatic nerve ligation (PSNL), acupuncture treatments on the acupoints GB30-GB34 (AP1), HT7-GV20 (AP2), or control points (CP) were performed for 4 weeks. Notably, the significant attenuations of mechanical allodynia and cognitive impairment were observed in the AP1 group, but not in PSNL, AP2, or CP groups. A random decision forest classifier based on the pain and cognitive functions displayed that the acupuncture group was clearly segregated from the other groups. We also demonstrated that acupuncture restored the reduced field excitatory post-synaptic potentials and was able to elevate the expression levels of glutamate receptors (NR2B and GluR1) in the hippocampus. Moreover, the expressions of Ca2+/calmodulin-dependent protein kinase II and synaptic proteins (pPSD-95 and pSyn-1) were enhanced by acupuncture treatment. These results suggest that acupuncture can enhance hippocampal long-term action through the regulation of the synaptic efficacy and that acupuncture may provide a viable option for managing both pain and cognitive functions associated with chronic neuropathic pain. |
| first_indexed | 2024-12-13T09:42:24Z |
| format | Article |
| id | doaj.art-f455c90b983d412aa0faf5319bbbc82f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T09:42:24Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-f455c90b983d412aa0faf5319bbbc82f2022-12-21T23:52:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-09-011310.3389/fnins.2019.00995479937Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in MiceJae-Hwan Jang0Jae-Hwan Jang1Jae-Hwan Jang2Yu-Kang Kim3Yu-Kang Kim4Won-Mo Jung5Hyung-Kyu Kim6Eun-Mo Song7Hee-Young Kim8Ju-Young Oh9Ju-Young Oh10Ju-Young Oh11Ji-Yeun Park12Yeonhee Ryu13Mi-Yeon Song14Hi-Joon Park15Hi-Joon Park16Hi-Joon Park17Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, South KoreaDepartment of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, Seoul, South KoreaBK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaAcupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, South KoreaDepartment of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, Seoul, South KoreaVUNO Inc., Seoul, South KoreaDepartment of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, South KoreaDepartment of Physical Medicine and Rehabilitation, Graduate School of Korean Medicine, Kyung Hee University, Seoul, South KoreaCollege of Korean Medicine, Daegu Haany University, Daegu, South KoreaAcupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, South KoreaDepartment of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, Seoul, South KoreaBK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaCollege of Korean Medicine, Daejeon University, Daejeon, South KoreaKorea Institute of Oriental Medicine, Daejeon, South KoreaDepartment of Physical Medicine and Rehabilitation, Graduate School of Korean Medicine, Kyung Hee University, Seoul, South KoreaAcupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, South KoreaDepartment of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, Seoul, South KoreaBK21 PLUS Korean Medicine Science Center, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaGrowing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain in mice. One week after the left partial sciatic nerve ligation (PSNL), acupuncture treatments on the acupoints GB30-GB34 (AP1), HT7-GV20 (AP2), or control points (CP) were performed for 4 weeks. Notably, the significant attenuations of mechanical allodynia and cognitive impairment were observed in the AP1 group, but not in PSNL, AP2, or CP groups. A random decision forest classifier based on the pain and cognitive functions displayed that the acupuncture group was clearly segregated from the other groups. We also demonstrated that acupuncture restored the reduced field excitatory post-synaptic potentials and was able to elevate the expression levels of glutamate receptors (NR2B and GluR1) in the hippocampus. Moreover, the expressions of Ca2+/calmodulin-dependent protein kinase II and synaptic proteins (pPSD-95 and pSyn-1) were enhanced by acupuncture treatment. These results suggest that acupuncture can enhance hippocampal long-term action through the regulation of the synaptic efficacy and that acupuncture may provide a viable option for managing both pain and cognitive functions associated with chronic neuropathic pain.https://www.frontiersin.org/article/10.3389/fnins.2019.00995/fullacupuncturepartial sciatic nerve ligationanalgesiacognitive impairmentglutamatergic receptor |
| spellingShingle | Jae-Hwan Jang Jae-Hwan Jang Jae-Hwan Jang Yu-Kang Kim Yu-Kang Kim Won-Mo Jung Hyung-Kyu Kim Eun-Mo Song Hee-Young Kim Ju-Young Oh Ju-Young Oh Ju-Young Oh Ji-Yeun Park Yeonhee Ryu Mi-Yeon Song Hi-Joon Park Hi-Joon Park Hi-Joon Park Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice Frontiers in Neuroscience acupuncture partial sciatic nerve ligation analgesia cognitive impairment glutamatergic receptor |
| title | Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice |
| title_full | Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice |
| title_fullStr | Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice |
| title_full_unstemmed | Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice |
| title_short | Acupuncture Improves Comorbid Cognitive Impairments Induced by Neuropathic Pain in Mice |
| title_sort | acupuncture improves comorbid cognitive impairments induced by neuropathic pain in mice |
| topic | acupuncture partial sciatic nerve ligation analgesia cognitive impairment glutamatergic receptor |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00995/full |
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