Rescue of Hepatic Phospholipid Remodeling Defect in iPLA<sub>2</sub>β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver

Rescue of Hepatic Phospholipid Remodeling Defect in iPLA<sub>2</sub>β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver

Polymorphisms of group VIA calcium-independent phospholipase A2 (iPLA<sub>2</sub>β or PLA2G6) are positively associated with adiposity, blood lipids, and Type-2 diabetes. The ubiquitously expressed iPLA<sub>2</sub>β catalyzes the hydrolysis of phospholipids (PLs) to generate...

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Bibliographic Details
Main Authors: Walee Chamulitrat, Chutima Jansakun, Huili Li, Gerhard Liebisch
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
PLA2G6
fatty liver
phospholipid remodeling
diet-induced obesity
morbidly obesity
choline and methionine deficiency
Online Access:https://www.mdpi.com/2218-273X/10/9/1332

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