Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Abstract Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age...

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Bibliographic Details
Main Authors: Christine Durier, Laetitia Ninove, Maeva Lefebvre, Anne Radenne, Corinne Desaint, Jacques Ropers, Rebecca Bauer, Said Lebbah, Diane Carette, Marie Lachatre, Anne-Sophie Lecompte, Dominique Deplanque, Elisabeth Botelho-Nevers, Anne Conrad, Bertrand Dussol, Zoha Maakaroun-Vermesse, Giovanna Melica, Jean-François Nicolas, Renaud Verdon, Jacques Kiladjian, Paul Loubet, Catherine Schmidt-Mutter, Christian Dualé, Séverine Ansart, Stéphane Priet, Axel Levier, Diana Molino, Louis-Victorien Vieillard, Béatrice Parfait, Jean-Daniel Lelièvre, Eric Tartour, Xavier de Lamballerie, Odile Launay, ANRS0002S CoviCompareP Group, AP-HP CoviCompareM Group, Biological resource centers, Laboratories, Trial coordination, Sponsor, Scientific Committee
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24409-w
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Summary:Abstract Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.
ISSN:2045-2322

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