ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS
Low serum albumin level is the strongest mortality-predictor in maintenance hemodialysis (MHD) patients. It is not known whether this association is consistent across all age groups, especially in the elderly. We examined the association of serum albumin and all–cause mortality in 105,523 MHD patien...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2012-06-01
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| Series: | Kidney Research and Clinical Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221191321200455X |
| _version_ | 1818498248609890304 |
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| author | Alla Victoroff Miklos Z Molnar Jennie Jing Elani Streja Vanessa Ravel Debbie Benner Csaba P Kovesdy Joel D Kopple Kamyar Kalantar-Zadeh |
| author_facet | Alla Victoroff Miklos Z Molnar Jennie Jing Elani Streja Vanessa Ravel Debbie Benner Csaba P Kovesdy Joel D Kopple Kamyar Kalantar-Zadeh |
| author_sort | Alla Victoroff |
| collection | DOAJ |
| description | Low serum albumin level is the strongest mortality-predictor in maintenance hemodialysis (MHD) patients. It is not known whether this association is consistent across all age groups, especially in the elderly. We examined the association of serum albumin and all–cause mortality in 105,523 MHD patients across different age groups using Cox models to estimate death hazard ratios for quarterly averaged serum albumin increments controlled for case–mix, comorbidity, dialysis dose, and available markers of malnutrition–inflammation–complex syndrome (MICS) in all age groups. In those <65 yr, higher alb>4.0 g/dL continues to provide incremental survival advantage (Panel A), whereas in patients >65 yr old, no additional survival gain is observed beyond 4.0−g/dL (Panels B-D).
High albumin levels are linearly associated with greater survival in all MHD patients although in the elderly gain stops at albumin >4.0 g/dL.fx1 |
| first_indexed | 2024-12-10T18:55:43Z |
| format | Article |
| id | doaj.art-f45a9aace81e460d9a6455676ea0de98 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-10T18:55:43Z |
| publishDate | 2012-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-f45a9aace81e460d9a6455676ea0de982022-12-22T01:37:10ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-06-01312A4110.1016/j.krcp.2012.04.422ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTSAlla VictoroffMiklos Z MolnarJennie JingElani StrejaVanessa RavelDebbie BennerCsaba P KovesdyJoel D KoppleKamyar Kalantar-ZadehLow serum albumin level is the strongest mortality-predictor in maintenance hemodialysis (MHD) patients. It is not known whether this association is consistent across all age groups, especially in the elderly. We examined the association of serum albumin and all–cause mortality in 105,523 MHD patients across different age groups using Cox models to estimate death hazard ratios for quarterly averaged serum albumin increments controlled for case–mix, comorbidity, dialysis dose, and available markers of malnutrition–inflammation–complex syndrome (MICS) in all age groups. In those <65 yr, higher alb>4.0 g/dL continues to provide incremental survival advantage (Panel A), whereas in patients >65 yr old, no additional survival gain is observed beyond 4.0−g/dL (Panels B-D). High albumin levels are linearly associated with greater survival in all MHD patients although in the elderly gain stops at albumin >4.0 g/dL.fx1http://www.sciencedirect.com/science/article/pii/S221191321200455X |
| spellingShingle | Alla Victoroff Miklos Z Molnar Jennie Jing Elani Streja Vanessa Ravel Debbie Benner Csaba P Kovesdy Joel D Kopple Kamyar Kalantar-Zadeh ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS Kidney Research and Clinical Practice |
| title | ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS |
| title_full | ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS |
| title_fullStr | ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS |
| title_full_unstemmed | ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS |
| title_short | ASSOCIATION OF SERUM ALBUMIN AND MORTALITY IN ELDERLY DIALYSIS PATIENTS |
| title_sort | association of serum albumin and mortality in elderly dialysis patients |
| url | http://www.sciencedirect.com/science/article/pii/S221191321200455X |
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